Histone deacetylase inhibitors
https://themeditary.com/dosage-information/zolinza-dosage-4580.html

Zolinza Dosage

Drug Detail:Zolinza (Vorinostat [ vor-in-o-stat ])

Generic Name: VORINOSTAT 100mg

Dosage Form: capsule

Drug Class: Histone deacetylase inhibitors

Contents
Uses Warnings Before Taking Dosage Side effects Interactions

Dosing Information

The recommended dose is 400 mg orally once daily with food.

Treatment may be continued as long as there is no evidence of progressive disease or unacceptable toxicity.

ZOLINZA capsules should not be opened or crushed [see How Supplied/Storage and Handling (16)].

Dose Modifications

For Toxicity

If a patient is intolerant to therapy, the dose may be reduced to 300 mg orally once daily with food. The dose may be further reduced to 300 mg once daily with food for 5 consecutive days each week, as necessary.

Hepatic Impairment

Reduce the starting dose to 300 mg orally once daily with food in patients with mild to moderate hepatic impairment (bilirubin 1 to 3 × ULN or AST greater than ULN). There is insufficient evidence to recommend a starting dose for patients with severe hepatic impairment (bilirubin greater than 3 × ULN) [see Use in Specific Populations (8.6) and Clinical Pharmacology (12.3)].

Share this Article
Latest News
Related Drugs