Brolucizumab-dbll injection is used to treat wet age-related macular degeneration (AMD; an ongoing disease of the eye that causes loss of the ability to see straight ahead and may make it more difficult to read, drive, or perform other daily activities). Brolucizumab-dbll injection is also used to treat diabetic macular edema (DME; an eye disease caused by diabetes that can lead to vision loss). Brolucizumab-dbll is in a class of medications called vascular endothelial growth factor A (VEGF-A) antagonists. It works by stopping abnormal blood vessel growth and leakage in the eye(s) that may cause vision loss.

Brolucizumab-dbll comes as a solution (liquid) to be injected into the eye by a doctor. If you are receiving brolucizumab-dbll injection to treat wet AMD, it is usually given in a doctor's office once every 25 to 31 days for the first 3 doses, then once every 8 to 12 weeks. If you are receiving brolucizumab-dbll injection to treat DME, it is usually given in a doctor's office once every 39 to 45 days for the first 5 doses, then once every 8 to 12 weeks.

Before you receive a brolucizumab-dbll injection, your doctor will clean your eye to prevent infection and numb your eye to reduce discomfort during the injection. You may feel pressure in your eye when the medication is injected. After your injection, your doctor will need to examine your eyes before you leave the office.

Brolucizumab-dbll controls wet AMD and DME, but does not cure it. Your doctor will watch you carefully to see how well brolucizumab-dbll works for you. Talk to your doctor about how long you should continue treatment with brolucizumab-dbll.

Ask your pharmacist or doctor for a copy of the manufacturer's information for the patient.

Before receiving brolucizumab-dbll injection,

• tell your doctor and pharmacist if you are allergic to brolucizumab-dbll, any other medications, or any of the ingredients in brolucizumab-dbll injection. Ask your pharmacist for a list of the ingredients.
• tell your doctor and pharmacist what other prescription and nonprescription medications, vitamins, nutritional supplements, and herbal products you are taking or plan to take.
• tell your doctor if you have an infection in or around the eye. Your doctor will probably tell you that you should not receive brolucizumab-dbll injection.
• tell your doctor if you have any medical conditions.
• tell your doctor if you are pregnant or plan to become pregnant. You should not become pregnant during your treatment with brolucizumab-dbll injection and for 1 month after your final dose. If you become pregnant while receiving brolucizumab-dbll injection, call your doctor.
• tell your doctor if you breast-feeding. Do not breast-feed while you are receiving brolucizumab-dbll injection and for 1 month after your final dose.
• you should know that brolucizumab-dbll injection may cause vision problems shortly after you receive the injection. Do not drive a car or operate machinery until your vision is back to normal.

If you miss an appointment to receive brolucizumab-dbll injection, call your doctor as soon as possible.

Unless your doctor tells you otherwise, continue your normal diet.

Some side effects from brolucizumab-dbll injection can be serious. If you experience any of these symptoms, call your doctor immediately or get emergency medical treatment:

• eye pain, redness, or sensitivity to light
• changes in vision
• seeing ''floaters'' or small specks
• bleeding in or around the eye
• swelling of the eye or eyelid
• rash, hives, itching, or redness

Brolucizumab-dbll may cause other side effects. Call your doctor if you have any unusual problems while receiving this medication.

If you experience a serious side effect, you or your doctor may send a report to the Food and Drug Administration's (FDA) MedWatch Adverse Event Reporting program online (http://www.fda.gov/Safety/MedWatch) or by phone (1-800-332-1088).

This medication may be prescribed for other uses; ask your doctor or pharmacist for more information.

Keep all appointments with your doctor.

Ask your pharmacist any questions you have about brolucizumab-dbll injection.

It is important for you to keep a written list of all of the prescription and nonprescription (over-the-counter) medicines you are taking, as well as any products such as vitamins, minerals, or other dietary supplements. You should bring this list with you each time you visit a doctor or if you are admitted to a hospital. It is also important information to carry with you in case of emergencies.