Latest Drugs, Latest Approval in ACE inhibitors with calcium channel blocking agents
What are ACE inhibitors with calcium channel blocking agents?
ACE inhibitors with calcium channel blocking agents is a combination medicine containing both an angiotensin-converting-enzyme inhibitor (ACE inhibitor) and a calcium channel blocker.This combination is often used to treat hypertension.
An ACE inhibitor blocks the angiotensin-converting-enzyme from converting angiotensin I to angiotensin II. This results in a decrease in angiotensin II causing vasodilation and therefore a reduction in blood pressure.
Calcium channel blockers block calcium from entering cells of the heart and smooth muscle in the walls of blood vessels. This results in vasodilation of the arteries, a reduction in heart contraction force, a slowing of heart rate and a reduction in aldosterone production. These effects cause a decrease in blood pressure in the hypertensive patient and a decrease in symptoms in patients with angina or ischemic heart disease.
