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Aminopenicillins are bactericidal beta-lactam antibiotics, which work by inhibiting bacterial cell wall synthesis. They are chemically similar to penicillin but have a broader spectrum of activity than penicillin. Aminopenicillins are not deactivated by acid hydrolysis so they can be administered orally, they are however susceptible to hydrolysis by beta-lactamase and therefore are sometimes given with beta-lactamase inhibitors. Aminopenicillins are effective against most gram-positive bacterial infections and gram-negative infections such as E.coli and H.influenza. They are used to treat upper and lower respiratory tract infections, endocarditis urinary tract infections, skin infections, and so on.