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Glycylcyclines are a new generation of antibiotics derived from tetracyclines. They were developed to overcome issues with bacterial resistance to tetracyclines.

Glycylcycline antibiotics inhibit bacterial reproduction by blocking bacterial protein synthesis. They have broad spectrum of activity against gram-negative and gram-positive bacteria, but are more potent against bacteria that is resistance to tetracyclines. Glycylcycline antibiotics are active against resistant organisms such as methicillin resistant staphylocci, penicillin-resistant streptococcus pneumoniae and vancomycin resistant enterococci.