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Peripheral vasodilators are agents which act on the most distal parts of the vascular system i.e. the arterioles and venules. They dilate these distal blood vessels and lower the blood pressure, therefore makes it easier for the heart to pump blood through these peripheral blood vessels (and therefore whole the body).

Peripheral vasodilators are used in the treatment of hypertension, acute myocardial infarction and heart failure.