Dry eye: One type of bacteria in eye microbiome may signal disease

Evan Walker
Evan Walker TheMediTary.Com |
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Scientists have found different bacteria spices in the eye microbiome of people with dry eye disease. ljubaphoto/Getty Images
  • Several areas of the body have a microbiome, including the gut, skin, mouth, nose, ear, and eyes.
  • Researchers have been studying the eye microbiome and its role in eye diseases such as dry eye.
  • Researchers from Stephen F. Austin State University have found the eye microbiomes of Healthy eyes and those with dry eye differ in their mix of microbes.
  • Scientists believe this finding could help improve treatments for not only dry eye but other eye conditions as well.

While everyone has heard about the Health Sciences" rationale="Governmental authority">microbiome that lives in a person’s gastrointestinal tract, there are also microbiomes in other parts of the body including the Health">skin, Health">mouth, Health">nose, Health">ear, and eyes.

Over the past few years, researchers have been focusing on studying the eye microbiome and its role in eye diseases, including dry eye — a condition affecting as much as 50% of the world’s population.

Now, a new study recently presented at Discover BMB, the annual meeting of the American Society for Biochemistry and Molecular Biology, reports how the eye microbiomes of healthy eyes and those with dry eye differ in their mix of microbes.

The study’s researchers from Stephen F. Austin State University believe this finding could help improve treatments for not only dry eye but other eye conditions as well.

For this study, Dr. Martynova-Van Kley and her team collected eye samples from 30 volunteer participants using a swab. They then performed 16S rRNA sequencing and bioinformatic analysis to discover what was included in the eye microbiomes of people with dry eye versus healthy eyes.

Upon analysis, the researchers found the bacteria species Streptococcus and Pedobacter were the dominant microbes in the ocular microbiomes of study participants with healthy eyes.

In the eye microbiomes of participants with dry eye, scientists discovered the Acinetobacter bacteria species was prevalent.

“It was surprising to know the eye microbiome with dry eye condition have mostly Acinetobacter species, but we found other ocular diseases like hypertension and high cholesterol have other species richness which are closely related to each other. Having a better idea of what causes dry eye condition is important to improve diagnosis, treatment, and prevention from this disease condition.”
— Dr. Alexandra Martynova-Van Kley

“Insights into the causes of dry eyes provide valuable information that can drive the development of novel therapeutic approaches, leading to better outcomes for individuals suffering from this condition,” she continued.

“Next steps will be increasing the sample size and understanding the signaling pathways associated with the indicator species in dry eye conditions. This can provide insight into metabolites that are responsible for the disease condition,” she added.

After reviewing this research, Dr. David Geffen, director of optometric and refractive services at the Gordon Schanzlin New Vision Institute in La Jolla, CA, told MNT he found it very interesting.

“If we can modify the microbiome of the eye to help with dry eye patients, a true breakthrough would be seen,” Dr. Geffen continued. “Dry eye is an exponential problem and this new take on it could prove to be the answer for millions of sufferers. I would expect many more researchers to start looking at this approach and coupling this with drug use.”

MNT also spoke about this study with Dr. Benjamin Bert, a board-certified ophthalmologist at MemorialCare Orange Coast Medical Center in Fountain Valley, CA.

Dr. Bert commented that this research helps to support a lot of what we’ve been discovering over the last number of years about dry eye and the multifactorial effects that it can have.

“[L]ooking at the change that can occur just to the normal bacteria that live on the surface of the eye shows that the treatment of dry eye in itself needs to be likely multifactorial. We’ve known for certain dry eye conditions and blepharitis that treating with antibiotics has helped, but the reason for that has always been a little bit murky. And I think studies like this that show that there’s a change in the normal bacteria that are on the surface of the eye support reasons why those treatments do have benefit to patients.”
— Dr. Benjamin Bert

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