Mediterranean diet may help lower depression risk in older women

Evan Walker
Evan Walker TheMediTary.Com |
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Following a Mediterranean diet, and particularly eating fish, is linked to a lower risk of depression — at least in women. Image credit: Stas Pylypets/Getty Images.
  • Close adherence to a Mediterranean diet is associated with a reduced risk of depressive symptoms in older women, according to a new study.
  • Consuming fish and monounsaturated oils, both part of the Mediterranean diet, proved particularly important for the association.
  • While the study involved women and men, researchers saw a greater beneficial association between consumption of a Mediterranean diet and depression for women.

A newly published study finds that following a Mediterranean diet is associated with a reduction of depression in older women.

The World Health Organization (WHO) estimates that depression affects about 5.7% of adults over the age of 60, and that the condition is 50% more common among women than men.

The new study, which appears in the British Journal of Nutrition, finds that women most closely adhering to a Mediterranean diet were around 60% less likely to experience depression.

This effect was not observed in men.

The Italian NutBrain study involved 325 men and 473 women who were aged 65–97, with a mean age of 73.

Each participant responded to a 102-item questionnaire regarding their daily diet, allowing researchers to calculate each person’s Mediterranean diet score (MDS). Individuals were divided into three groups, or tertiles, based on how closely they followed the diet.

Participants were also assessed for depression using the Center for Epidemiological Studies Depression Scale.

Overall, 19.8% of the study’s participants reported symptoms of depression — 27.9% of women compared with 8.0% of men.

People who scored within the top third of MDS scores were 55% less likely to experience depressive symptoms. Women in this tertile were around 60% less likely to report symptoms of depression.

Digging deeper into dietary elements, the researchers observed an association between eating more fish and monounsaturated fatty acids, compared with unsaturated fatty acids, and a greater reduction in depression.

While eating more fish was linked to a 44% overall reduction in depression risk for those in the top third of the tertiles, the reduction for women was 56%. For each gram of fish consumed per day, the risk fell by 2% for women.

When three or more servings of fresh fish were consumed weekly, the risk of depression was reduced by 62%; there was no association with canned tuna.

Monounsaturated fatty acids found in foods such as olive oil, peanuts, avocados, almonds, pecans, hazelnuts, and cashews are an important component of the Mediterranean diet.

The researchers observed that women who consumed a greater proportion of monounsaturated fatty acids versus saturated fatty acids had a 42% lower risk of depressive symptoms.

Nut and fruit consumption reduced the risk of depressive symptoms by 82% for men.

Michelle Routhenstein, registered dietician and nutritionist at, not involved in this study, told Medical News Today that:

“The observation that the protective effects of the Mediterranean diet components primarily affect women is surprising, given the potential biological mechanisms, such as vitamin D deficiency and alterations in brain-cell membrane composition, which are typically not gender-specific.”

At the same time, Routhenstein noted that its is important to remember that depressive symptoms were much more prevalent in women than in men. Then, she added, “women with depressive symptoms were more likely to be unmarried, live alone, take more medication, and to have poorer perceived health status.”

By contrast, registered dietician nutritionist Kristin Kirkpatrick, also not involved in this research, told us she was not surprised by the greater benefit to women of the Mediterranean diet, given the results of other existing research.

She reported that “[a] 2021 study found that non-nutrient rich diets had a greater adverse impact on women’s mental Health than men, and a 2018 study found that men and women had differences in dietary patterns and mental well-being.”

As for why this disparity may exist, Kirkpatrick cited some research that suggests there could be “differences in the brain, or perhaps it also relates to the data showing that women are more susceptible to mental illness than men and that women react differently to various stressors than men as well.”

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