Applies to acyclovir/hydrocortisone topical: topical application cream.

Serious side effects

Along with its needed effects, acyclovir/hydrocortisone topical may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur while taking acyclovir / hydrocortisone topical:

Rare

• Burning, itching, redness, rash, swelling, soreness, or tingling at the application site
• change in skin color at the application site
• dryness or flaking of the skin
• flushing or redness of the skin
• unusually warm skin

Incidence not known

• Blistering, burning, or crusting of the skin
• itching, scaling, severe redness, soreness, or swelling of the skin

For Healthcare Professionals

Applies to acyclovir / hydrocortisone topical: topical cream.

General

The most frequently reported side effects were local skin reactions and included drying or flaking of the skin; burning or tingling; erythema; pigmentation changes; and application site reactions including signs/symptoms of inflammation.^[Ref]

Local

Frequency not reported: Dry skin, flaking skin, burning, tingling, erythema, pigmentation changed, inflammation^[Ref]

Hypersensitivity

Frequency not reported: Contact allergy, sensitization^[Ref]

Dermatologic

Frequency not reported: Contact dermatitis^[Ref]