Note: This document contains side effect information about alectinib. Some dosage forms listed on this page may not apply to the brand name Alecensa.

Summary

Common side effects of Alecensa include: cough, dyspnea, increased creatine phosphokinase in blood specimen, increased serum aspartate aminotransferase, musculoskeletal pain, and myalgia. Other side effects include: bradycardia, and increased serum bilirubin. Continue reading for a comprehensive list of adverse effects.

Applies to alectinib: oral capsules.

Side effects include:

Fatigue, constipation, edema, myalgia, anemia.

For Healthcare Professionals

Applies to alectinib: oral capsule.

Hematologic

Very common (10% or more): Anemia (62%), lymphopenia (14%), neutropenia (14%)

Postmarketing reports: Hemolytic anemia^[Ref]

Hepatic

Very common (10% or more): Increased AST (51%), increased alkaline phosphatase (47%), hyperbilirubinemia (39%), increased ALT (34%)^[Ref]

Musculoskeletal

Very common (10% or more): Increased CPK (43%), myalgia/musculoskeletal pain (29%), back pain (12%), back pain (12%)^[Ref]

Other

Very common (10% or more): Fatigue/asthenia (26%), edema (e.g., peripheral edema, edema, eyelid edema, localized edema, face edema) (22%)^[Ref]

Metabolic

Very common (10% or more): Hyperglycemia (36%), hypocalcemia (32%), hypokalemia (29%), hypophosphatemia (21%), hyponatremia (20%), increased weight (11%)^[Ref]

Gastrointestinal

Very common (10% or more): Constipation (34%), nausea (18%), diarrhea (16%), vomiting (12%)^[Ref]

Renal

Very common (10% or more): Increased creatinine (e.g., increased blood creatinine, creatinine renal clearance decreased, glomerular filtration rate decreased, acute kidney injury) (28%)^[Ref]

Dermatologic

Very common (10% or more): Rash (e.g., acneiform dermatitis, erythema, and different types of rash [macular, papular, maculopapular, generalized, and pruritic]) (15%)

Common (1% to 10%): Photosensitivity^[Ref]

Nervous system

Very common (10% or more): Headache (17%)

Common (1% to 10%): Dysgeusia/hypogeusia^[Ref]

Respiratory

Very common (10% or more): Cough (19%), dyspnea (16%)

Uncommon (0.1% to 1%): Interstitial lung disease^[Ref]

Ocular

Very common (10% or more): Vision disorder (e.g., blurred vision, vitreous floaters, visual impairment, reduced visual acuity, asthenopia, diplopia) (10%)^[Ref]

Cardiovascular

Very common (10% or more): Bradycardia (11%)^[Ref]