Applies to aminophylline: intravenous solution.
Serious side effects of Aminophylline
Along with its needed effects, aminophylline may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.
Check with your doctor or nurse immediately if any of the following side effects occur while taking aminophylline:
Incidence not known
- Chest pain or discomfort
- dizziness
- fainting
- fast, slow, or irregular heartbeat
- increase in urine volume
- lightheadedness
- persistent vomiting
- pounding or rapid pulse
- seizures
- shakiness
Get emergency help immediately if any of the following symptoms of overdose occur while taking aminophylline:
Symptoms of overdose
- Abdominal or stomach pain
- blurred vision
- confusion
- confusion about identity, place, and time
- dark-colored urine
- decrease in frequency of urination
- decreased urine
- diarrhea
- difficulty in passing urine (dribbling)
- dizziness, faintness, or lightheadedness when getting up suddenly from a lying or sitting position
- dry mouth
- fast, pounding, or irregular heartbeat or pulse
- fever
- increased thirst
- irregular heartbeat
- loss of appetite
- mood changes
- muscle cramps or spasms
- muscle pain or stiffness
- nausea or vomiting
- nervousness
- numbness or tingling in the hands, feet, or lips
- pain or discomfort in the arms, jaw, back, or neck
- painful urination
- shakiness in the legs, arms, hands, or feet
- shortness of breath
- sweating
- unusual tiredness or weakness
- vomiting of blood or material that looks like coffee grounds
Other side effects of Aminophylline
Some side effects of aminophylline may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects.
Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:
Incidence not known
- Headache
- irritability
- restlessness
- sleeplessness
- trouble sleeping
- unable to sleep
For Healthcare Professionals
Applies to aminophylline: compounding powder, intravenous solution, oral solution, oral tablet, oral tablet extended release, rectal suppository.
General
The most common adverse events with peak serum theophylline levels under 20 mcg/mL are transient caffeine-like events such as nausea, vomiting, headache, and insomnia. When serum theophylline exceeds 20 mcg/mL a wide range of adverse events may occur, including persistent vomiting, cardiac arrhythmias, and potentially lethal intractable seizures.[Ref]
Gastrointestinal
Frequency not reported: Nausea, vomiting, persistent vomiting, diarrhea, abdominal pain, hematemesis[Ref]
Cardiovascular
Frequency not reported: Multifocal atrial tachycardia and flutter (in patients with hypoxia secondary to COPD), sinus tachycardia, other supraventricular tachycardias, ventricular premature beats, atrial fibrillation or flutter, ventricular arrhythmias with hemodynamic instability, hypotension/shock[Ref]
Nervous system
Frequency not reported: Headache, seizures[Ref]
Hypersensitivity
Rare (less than 0.1%): Severe allergic reactions of the skin (including exfoliative dermatitis)[Ref]
Metabolic
Frequency not reported: Hypokalemia, hyperglycemia, acid/base disturbance[Ref]
Musculoskeletal
Frequency not reported: Fine skeletal muscle tremors, rhabdomyolysis[Ref]
Psychiatric
Frequency not reported: Insomnia, irritability, restlessness, nervousness, disorientation[Ref]
Genitourinary
Frequency not reported: Transient diuresis[Ref]
Other
Frequency not reported: Tremors, death[Ref]
Dermatologic
Frequency not reported: Contact dermatitis[Ref]
