Note: This document contains side effect information about lubiprostone. Some dosage forms listed on this page may not apply to the brand name Amitiza.
Summary
Common side effects of Amitiza include: diarrhea, headache, and nausea. Other side effects include: urinary tract infection, abdominal distention, abdominal pain, dizziness, peripheral edema, sinusitis, vomiting, and flatulence. Continue reading for a comprehensive list of adverse effects.
Applies to lubiprostone: oral capsule liquid filled.
Serious side effects of Amitiza
Along with its needed effects, lubiprostone (the active ingredient contained in Amitiza) may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.
Check with your doctor immediately if any of the following side effects occur while taking lubiprostone:
More common
- Diarrhea
- full or bloated feeling or pressure in the stomach
- nausea
- stomach pain
- swelling of the abdominal or stomach area
Less common
- Black, tarry stools
- blood in the stools
- chest discomfort or pain
- chills
- colds
- cough
- difficult or labored breathing
- fever
- general feeling of discomfort or illness
- headache
- increased sweating
- joint pain
- loss of appetite
- loss of bowel control
- muscle aches and pains
- runny nose
- shivering
- sore throat
- stomach discomfort
- sweating
- tightness in the chest
- trouble sleeping
- unusual tiredness or weakness
- vomiting
Incidence not known
- Blurred vision
- confusion
- difficulty with swallowing
- dizziness, faintness, or lightheadedness when getting up suddenly from a lying or sitting position
- fainting
- fast, pounding, or irregular heartbeat or pulse
- hives or skin rash
- puffiness or swelling of the eyelids or around the eyes, face, lips, or tongue
- stomach tenderness
- swelling
Get emergency help immediately if any of the following symptoms of overdose occur while taking lubiprostone:
Symptoms of overdose
- Dry heaves
- dry mouth
- feeling of warmth
- lack or loss of strength
- paleness of the skin
- redness of the face, neck, arms, and occasionally, upper chest
- severe, unusual tiredness or weakness
- weight loss
Other side effects of Amitiza
Some side effects of lubiprostone may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects.
Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:
More common
- Excess air or gas in the stomach or intestines
- passing gas
Less common
- Belching
- bladder pain
- bloody or cloudy urine
- change in taste
- cold sweats
- difficult, burning, or painful urination
- difficulty with moving
- discouragement
- dizziness
- fear or nervousness
- feeling sad or empty
- frequent urge to urinate
- heartburn
- increased weight
- indigestion
- irritability
- loss of interest or pleasure
- loss of taste
- lower back or side pain
- muscle cramps
- muscle stiffness
- stomach upset
- swollen joints
- tingling of the hands or feet
- unusual drowsiness, dullness, tiredness, or feeling of sluggishness
For Healthcare Professionals
Applies to lubiprostone: oral capsule.
Gastrointestinal
Very common (10% or more): Nausea (up to 29%), diarrhea (up to 12%)
Common (1% to 10%): Abdominal pain, abdominal distention, flatulence, vomiting, loose stools, abdominal discomfort, dyspepsia, dry mouth
Frequency not reported: Intestinal functional disorder, constipation, eructation, fecal incontinence, defecation urgency, frequent bowel movements, gastroesophageal reflux disease, gastritis, hard feces, rectal hemorrhage, pollakiuria
Postmarketing reports: Ischemic colitis[Ref]
Nervous system
Very common (10% or more): Headache (up to 11%)
Common (1% to 10%): Dizziness
Uncommon (0.1% to 1%): Syncope
Frequency not reported: Dysgeusia, tremor, lethargy[Ref]
Cardiovascular
Common (1% to 10%): Palpitations, hot flush
Postmarketing reports: Tachycardia/increased heart rate, hypotension[Ref]
Dermatologic
Common (1% to 10%): Hyperhidrosis
Frequency not reported: Cold sweat, erythema
Postmarketing reports: Rash/urticaria[Ref]
Other
Common (1% to 10%): Edema, fatigue, chest discomfort/pain, peripheral edema
Frequency not reported: Influenza, pain
Postmarketing reports: Malaise, asthenia, swelling[Ref]
Respiratory
Common (1% to 10%): Dyspnea
Frequency not reported: Pharyngolaryngeal pain, cough
Postmarketing reports: Throat tightness[Ref]
Musculoskeletal
Uncommon (0.1% to 1%): Muscle spasms
Frequency not reported: Muscle cramps, joint swelling, myalgia, fibromyalgia[Ref]
Genitourinary
Frequency not reported: Urinary tract infection[Ref]
Hepatic
Frequency not reported: Increased ALT and AST[Ref]
Metabolic
Frequency not reported: Electrolyte imbalance, decreased appetite, decreased blood potassium, increased weight, anorexia[Ref]
Psychiatric
Frequency not reported: Anxiety, depression[Ref]
Hypersensitivity
Postmarketing reports: Hypersensitivity/allergic-type reactions[Ref]