Note: This document contains side effect information about disulfiram. Some dosage forms listed on this page may not apply to the brand name Antabuse.
Applies to disulfiram: oral tablets.
Warning
- Never administer to a patient in a state of alcohol intoxication or without patient's full knowledge; instruct relatives accordingly.a b
Side effects include:
Cholestatic or fulminant hepatitis, hepatic failure, skin eruptions (e.g., acneiform eruptions, allergic dermatitis), drowsiness, fatigue, impotence, headache, metallic or garlic-like aftertaste, psychotic reactions. Optic or peripheral neuritis, polyneuritis, or peripheral neuropathy also may occur.
For Healthcare Professionals
Applies to disulfiram: oral tablet.
Other
Frequency not reported: Fatigue[Ref]
Hepatic
Rare (less than 0.1%): Altered liver function tests
Frequency not reported: Hepatic cell damage, hepatitis (cholestatic and fulminant), hepatic failure resulting in transplant or death, jaundice, cirrhosis[Ref]
Nervous system
Frequency not reported: Drowsiness, peripheral neuritis, encephalopathy, polyneuritis, peripheral neuropathy, headache, seizures, lethargy[Ref]
Dermatologic
Frequency not reported: Skin eruptions, acneiform eruptions, allergic dermatitis, maculopapular rash[Ref]
Gastrointestinal
Frequency not reported: Nausea, vomiting, halitosis, metallic or garlic-like aftertaste, stomach upset[Ref]
Ocular
Frequency not reported: Optic neuritis, eye pain or tenderness, changes in vision[Ref]
Genitourinary
Frequency not reported: Decreased libido[Ref]
Psychiatric
Frequency not reported: Psychotic reactions, depression, paranoia, schizophrenia, mania, confusion, personality changes, disorientation, memory impairment[Ref]
