Note: This document contains side effect information about lymphocyte immune globulin, anti-thy (equine). Some dosage forms listed on this page may not apply to the brand name Atgam.
Applies to lymphocyte immune globulin, anti-thy (equine): parenteral concentrate for injection.
Warning
- Should be used only by clinicians experienced in immunosuppressive therapy for the management of renal transplant or aplastic anemia patients.b
- Patients receiving antithymocyte globulin (equine) should be treated in facilities equipped and staffed with adequate laboratory and supportive medical resources.b
Side effects include:
Renal allotransplantation: Fever, chills, leukopenia, thrombocytopenia, dermatologic reactions (rash, pruritus, urticaria, wheal and flare).
Aplastic anemia: Fever, chills, skin reactions, arthralgia, headache, myalgia, nausea, chest pain, phlebitis, serum sickness.
For Healthcare Professionals
Applies to lymphocyte immune globulin, anti-thy (equine): intravenous solution.
Hypersensitivity
Uncommon (0.1% to 1%): Anaphylactic reaction[Ref]
Dermatologic
Very common (10% or more): Rash (26%)
Common (1% to 10%): Urticaria, pruritus, vomiting, diarrhea, abdominal pain upper
Uncommon (0.1% to 1%): Herpes simplex, allergic dermatitis, toxic epidermal necrolysis (TEN)
Postmarketing reports: Hyperhidrosis[Ref]
Musculoskeletal
Very common (10% or more): Arthralgia (17%)
Common (1% to 10%): Chest pain, back pain[Ref]
Gastrointestinal
Common (1% to 10%): Nausea
Uncommon (0.1% to 1%): Stomatitis
Postmarketing reports: Abdominal pain, GI hemorrhage, GI perforation, oral pain[Ref]
Cardiovascular
Common (1% to 10%): Thrombophlebitis, hypertension, hypotension, bradycardia, arteriovenous fistula thrombosis, tachycardia, iliac vein occlusion
Postmarketing reports: Congestive heart failure, deep vein thrombosis, vasculitis[Ref]
Hematologic
Very common (10% or more): Thrombocytopenia (22%), leukopenia (18%)
Postmarketing reports: Anemia, eosinophilia, granulocytopenia, hemolysis, hemolytic anemia, neutropenia, pancytopenia[Ref]
Respiratory
Common (1% to 10%): Dyspnea
Uncommon (0.1% to 1%): Pleural effusion, hiccups, laryngospasm, pulmonary edema
Postmarketing reports: Apnea, cough, epistaxis, oropharyngeal pain[Ref]
Nervous system
Common (1% to 10%): Headache, dizziness
Uncommon (0.1% to 1%): Convulsion, encephalitis, paresthesia
Postmarketing reports: Dyskinesia, Syncope, tremor[Ref]
Local
Common (1% to 10%): Infusion site pain
Postmarketing reports: Infusion site erythema, infusion site swelling[Ref]
Renal
Uncommon (0.1% to 1%): Renal function test abnormal, renal artery thrombosis
Postmarketing reports: Kidney rupture, renal failure acute[Ref]
Ocular
Uncommon (0.1% to 1%): Periorbital edema[Ref]
Metabolic
Uncommon (0.1% to 1%): Night sweats, hyperglycemia, proteinuria
Postmarketing reports: Flank pain, muscle rigidity, myalgia, pain in extremity[Ref]
Hepatic
Common (1% to 10%): Liver function test abnormal[Ref]
Immunologic
Common (1% to 10%): Infection
Uncommon (0.1% to 1%): Serum sickness
Postmarketing reports: Hepatitis viral, localized infection, systemic infection[Ref]
Psychiatric
Uncommon (0.1% to 1%): Agitation
Postmarketing reports: Confusion, disorientation[Ref]
Other
Very common (10% or more): Pyrexia (40%), chills (27%)
Common (1% to 10%): Edema, lymphadenopathy, asthenia, malaise, wound dehiscence
Postmarketing reports: Aplasia, pain[Ref]
