Note: This document contains side effect information about hydralazine / isosorbide dinitrate. Some dosage forms listed on this page may not apply to the brand name BiDil.
Summary
Common side effects of BiDil include: dizziness, headache, and nausea. Other side effects include: hypotension, and paresthesia. Continue reading for a comprehensive list of adverse effects.
Applies to hydralazine / isosorbide dinitrate: oral tablet.
Serious side effects of BiDil
Along with its needed effects, hydralazine/isosorbide dinitrate may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.
Check with your doctor immediately if any of the following side effects occur while taking hydralazine/isosorbide dinitrate:
More common
- Blurred vision
- confusion
- dizziness, faintness, or lightheadedness when getting up suddenly from a lying or sitting position
- sweating
- unusual tiredness or weakness
Less common
- Fainting
- fast, pounding, or irregular heartbeat or pulse
Incidence not known
- Abdominal or stomach cramps or pain
- black, tarry stools
- bloating or swelling of the face, arms, hands, lower legs, or feet
- chest pain or discomfort
- dark urine
- diarrhea
- difficult or labored breathing
- fever or chills
- headache, severe and throbbing
- joint pain
- light-colored stools
- lower back or side pain
- mood or mental changes
- muscle aches, cramps, or stiffness
- pain in the arms or legs
- painful or difficult urination
- pale skin
- shortness of breath
- sores, ulcers, or white spots on the lips or inside the mouth
- unusual behavior, such as disorientation to time or place, failure to recognize people, hyperactivity, or restlessness
- unusual bruising or bleeding
- unusual weight gain or loss
- yellow eyes and skin
Other side effects of BiDil
Some side effects of hydralazine / isosorbide dinitrate may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects.
Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:
More common
- Constipation
- headache
- nausea or vomiting
Less common
- Burning, crawling, itching, numbness, prickling, "pins and needles", or tingling feelings
- cough
- pain or tenderness around the eyes and cheekbones
- stuffy or runny nose
Incidence not known
- Change in urine color
- continuing ringing, buzzing or other unexplained noise in the ears
- feeling of constant movement of self or surroundings
- feeling of warmth
- inability to have or keep an erection
- pinpoint red or purple spots on the skin
- redness of the face, neck, arms and occasionally, upper chest
- sensation of spinning
- stomach soreness or discomfort
For Healthcare Professionals
Applies to hydralazine / isosorbide dinitrate: oral tablet.
General
The most common side effects were headache, dizziness, asthenia, and nausea.[Ref]
Nervous system
Very common (10% or more): Headache (50%), dizziness (32%)
Common (1% to 10%): Paresthesia
Postmarketing reports: Tinnitus, dysgeusia, hypoesthesia, migraine, syncope[Ref]
Other
Very common (10% or more): Asthenia (14%)
Postmarketing reports: Vertigo, facial pain, chest discomfort, chest pain, peripheral edema[Ref]
Gastrointestinal
Very common (10% or more): Nausea (10%)
Common (1% to 10%): Vomiting
Postmarketing reports: Abdominal discomfort, constipation[Ref]
Cardiovascular
Common (1% to 10%): Hypotension, ventricular tachycardia
Postmarketing reports: Palpitations, flushing[Ref]
Ocular
Common (1% to 10%): Amblyopia
Postmarketing reports: Eyelid edema, vision blurred[Ref]
Respiratory
Common (1% to 10%): Sinusitis
Postmarketing reports: Dyspnea[Ref]
Dermatologic
Postmarketing reports: Erythema, hyperhidrosis, pruritus, face swelling[Ref]
Genitourinary
Postmarketing reports: Chromaturia, erectile dysfunction[Ref]
Musculoskeletal
Postmarketing reports: Pain in extremity, myalgia[Ref]
Renal
Postmarketing reports: Pulmonary renal syndrome[Ref]
