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Home > Drugs > Multikinase inhibitors > Binimetinib > Binimetinib Side Effects
Multikinase inhibitors

Binimetinib Side Effects

Applies to binimetinib: oral tablet.

Serious side effects of Binimetinib

Along with its needed effects, binimetinib may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur while taking binimetinib:

More common

  • Bleeding gums
  • bloating or swelling of the face, arms, hands, lower legs, or feet
  • blurred vision or any other change in vision
  • chest pain
  • coughing up blood
  • decreased urine output
  • difficulty in breathing or swallowing
  • dilated neck veins
  • dizziness
  • extreme tiredness or weakness
  • fever
  • headache
  • hoarseness
  • increased menstrual flow or vaginal bleeding
  • irregular breathing
  • irregular heartbeat
  • irritation
  • itching, hives, skin rash
  • joint pain, stiffness, or swelling
  • nervousness
  • nosebleed
  • paralysis
  • pounding in the ears
  • prolonged bleeding from cuts
  • rapid weight gain
  • red or black, tarry stools
  • red or dark brown urine
  • redness of the skin
  • slow or fast heartbeat
  • stomach cramps
  • tenderness
  • tightness in the chest
  • tingling of the hands or feet
  • trouble seeing
  • unusual tiredness or weakness
  • unusual weight gain or loss
  • watery or bloody diarrhea

Other side effects of Binimetinib

Some side effects of binimetinib may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects.

Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common

  • Constipation
  • diarrhea
  • nausea
  • stomach pain
  • vomiting

For Healthcare Professionals

Applies to binimetinib: oral tablet.

Hematologic

Very common (10% or more): Anemia (36%), hemorrhage (19%), leukopenia (13%), lymphoma (13%), neutropenia (13%)

Common (1% to 10%): Venous thromboembolism (VTE)[Ref]

Hypersensitivity

Common (1% to 10%): Hypersensitivity[Ref]

Musculoskeletal

Uncommon (0.1% to 1%): Rhabdomyolysis[Ref]

Ocular

Very common (10% or more): Retinopathy (20%), visual impairment (20%)

Common (1% to 10%): Retinal detachment, macular edema, uveitis

Uncommon (0.1% to 1%): Retinal vein occlusion[Ref]

Metabolic

Very common (10% or more): Hyponatremia (18%), peripheral edema (13%)[Ref]

Hepatic

Very common (10% or more): Increased gamma glutamyl transferase (45%)

Common (1% to 10%): Alanine aminotransferase (ALT) increased, aspartate aminotransferase (AST) increased

Uncommon (0.1% to 1%): Alkaline phosphatase increased[Ref]

Respiratory

Uncommon (0.1% to 1%): Interstitial lung disease[Ref]

Other

Very common (10% or more): Fatigue (43%), pyrexia (18%)[Ref]

Nervous system

Very common (10% or more): Dizziness (15%)[Ref]

Renal

Very common (10% or more): Increased creatinine (93%), increased creatine phosphokinase (58%)[Ref]

Cardiovascular

Very common (10% or more): Hypertension (11%)

Common (1% to 10%): Cardiomyopathy, fatal intracranial hemorrhage (in the setting of new or progressive brain metastases)[Ref]

Dermatologic

Very common (10% or more): Rash (22%)

Common (1% to 10%): Panniculitis[Ref]

Gastrointestinal

Very common (10% or more): Nausea (41%), diarrhea (36%), vomiting (30%), abdominal pain (28%), constipation (22%)

Common (1% to 10%): Rectal hemorrhage, hematochezia, hemorrhoidal hemorrhage, colitis[Ref]

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