Drug Detail:Cefepime (injection) (Cefepime (injection) [ sef-e-peem ])
Drug Class: Fourth generation cephalosporins
Cefepime Levels and Effects while Breastfeeding
Summary of Use during Lactation
Although no information is available on the use of cefepime during breastfeeding, the levels in breastmilk appear to be low and cephalosporins are generally not be expected to cause adverse effects in breastfed infants. Occasionally disruption of the infant's gastrointestinal flora, resulting in diarrhea or thrush have been reported with cephalosporins, but these effects have not been adequately evaluated. Cefepime is acceptable in nursing mothers.
Drug Levels
Maternal Levels. The manufacturer reports that the concentration of cefepime in breastmilk is about 0.5 mcg/mL, following a single intravenous dose of 1 gram. This is consistent with the low levels of other cephalosporins in breastmilk.
Infant Levels. Relevant published information was not found as of the revision date.
Effects in Breastfed Infants
Relevant published information was not found as of the revision date.
Effects on Lactation and Breastmilk
Relevant published information was not found as of the revision date.
Alternate Drugs to Consider
Ceftazidime, Ceftriaxone
Substance Identification
Substance Name
Cefepime
CAS Registry Number
88040-23-7
Drug Class
Breast Feeding
Lactation
Milk, Human
Anti-Infective Agents
Antibacterial Agents
Cephalosporins
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- Drug Levels and Effects
- Substance Identification