Loncastuximab Tesirine Levels and Effects while Breastfeeding
Summary of Use during Lactation
No information is available on the clinical use of loncastuximab tesirine during breastfeeding. Because loncastuximab is a large protein molecule with a molecular weight of about 151,000 Da, the amount in milk is likely to be very low. It is also likely to be partially destroyed in the infant's gastrointestinal tract and absorption by the infant is probably minimal. Loncastuximab is conjugated with SG3249, a small-molecule alkylating agent that might enter milk and be absorbed by the infant. Because of the potential for serious adverse reactions in the breastfed infant, the manufacturer recommends that women not breastfeed during treatment and for 3 months after the final dose.
Drug Levels
Maternal Levels. Relevant published information was not found as of the revision date.
Infant Levels. Relevant published information was not found as of the revision date.
Effects in Breastfed Infants
Relevant published information was not found as of the revision date.
Effects on Lactation and Breastmilk
Relevant published information was not found as of the revision date.
Substance Identification
Substance Name
Loncastuximab Tesirine
CAS Registry Number
1879918-31-6
Drug Class
Breast Feeding
Lactation
Milk, Human
Antibodies, Monoclonal, Humanized
Antineoplastic Agents
Disclaimer: Information presented in this database is not meant as a substitute for professional judgment. You should consult your healthcare provider for breastfeeding advice related to your particular situation. The U.S. government does not warrant or assume any liability or responsibility for the accuracy or completeness of the information on this Site.
