Drug Detail:Pembrolizumab (Pembrolizumab [ pem-broe-liz-ue-mab ])
Drug Class: Anti-PD-1 and PD-L1 monoclonal antibodies (immune checkpoint inhibitors)
No information is available on the clinical use of pembrolizumab during breastfeeding. Because pembrolizumab is a large protein molecule with a molecular weight of about 149,000 Da, the amount in milk is likely to be very low. It is also likely to be partially destroyed in the infant's gastrointestinal tract and absorption by the infant is probably minimal. Until more data become available, pembrolizumab should be used with caution during breastfeeding, especially while nursing a newborn or preterm infant. The manufacturer recommends that breastfeeding be discontinued during pembrolizumab therapy and for 4 months after the last dose.
Maternal Levels. Relevant published information was not found as of the revision date.
Infant Levels. Relevant published information was not found as of the revision date.
Relevant published information was not found as of the revision date.
Relevant published information was not found as of the revision date.
Pembrolizumab
1374853-91-4
Breast Feeding
Lactation
Milk, Human
Antibodies, Monoclonal, Humanized
Antineoplastic Agents
Biological Response Modifiers
Immunologic Adjuvants
Immune Checkpoint Inhibitors
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