Note: This document contains side effect information about nebivolol. Some dosage forms listed on this page may not apply to the brand name Bystolic.

Summary

More frequent side effects include: fatigue. Continue reading for a comprehensive list of adverse effects.

Applies to nebivolol: oral tablets.

Side effects include:

Headache, fatigue, dizziness, diarrhea, nausea.

For Healthcare Professionals

Applies to nebivolol: oral tablet.

General

The more frequently reported side effects in patients treated for hypertension were headache, dizziness, and fatigue; additionally, bradycardia was frequently reported in patients treated for chronic heart failure.^[Ref]

Cardiovascular

Very common (10% or more): Bradycardia (up to 11%)

Common (1% to 10%): Cardiac failure aggravation, edema, postural hypotension, first degree atrioventricular (AV) block, atrial fibrillation, hypertension, angina pectoris, chest pain

Uncommon (0.1% to 1%): Heart failure, slowed AV conduction, AV block (both second and third degree), hypotension, increased intermittent claudication, edema of the lower limbs,

Postmarketing reports: Raynaud's phenomenon, myocardial infarction, peripheral ischemia^[Ref]

Bradycardia was a dose-related effect in hypertensive patients. Bradycardia occurred more frequently in chronic heart failure patients (11%) than hypertensive patients (1%) at doses of 20 to 40 mg.

Aggravation of cardiac failure occurred in 19% of patients with chronic heart failure compared to 21.3% of placebo-treated patients in the SENIORS (Study on the Effects of Nebivolol Interventions on Outcomes and Rehospitalizations in Seniors with heart failure; n = 2128; median age = 75.2 years). Heart failure occurred in 0.1% to 1% of hypertensive patients.^[Ref]

Nervous system

Very common (10% or more): Dizziness (up to 11%)

Common (1% to 10%): Headache, paresthesia, somnolence, hypoesthesia

Uncommon (0.1% to 1%): Vertigo

Very rare (less than 0.01%): Syncope^[Ref]

Respiratory

Common (1% to 10%): Dyspnea, exacerbated dyspnea, common cold, coughing, bronchitis, pharyngitis

Uncommon (0.1% to 1%): Bronchospasm

Postmarketing reports: Acute pulmonary edema^[Ref]

Dermatologic

Common (1% to 10%): Increased sweating

Uncommon (0.1% to 1%): Pruritus, erythematous rash

Very rare (less than 0.01%): Psoriasis aggravated

Frequency not reported: Angioneurotic edema, urticaria

Postmarketing reports: Rash, skin disorders^[Ref]

Musculoskeletal

Common (1% to 10%): Myalgia, arthrosis, back pain^[Ref]

Gastrointestinal

Common (1% to 10%): Constipation, diarrhea, nausea

Uncommon (0.1% to 1%): Dyspepsia, flatulence, vomiting

Frequency not reported: Abdominal pain^[Ref]

Other

Common (1% to 10%): Tiredness, drug intolerance, pain, injury, fatigue

Frequency not reported: Asthenia^[Ref]

Psychiatric

Common (1% to 10%): Nervousness

Uncommon (0.1% to 1%): Nightmares, depression, insomnia, anxiety^[Ref]

Genitourinary

Uncommon (0.1% to 1%): Impotence^[Ref]

Ocular

Uncommon (0.1% to 1%): Impaired vision^[Ref]

Hematologic

Frequency not reported: Decreased platelet count

Postmarketing reports: Thrombocytopenia^[Ref]

Renal

Frequency not reported: Increased BUN

Postmarketing reports: Acute renal failure^[Ref]

Metabolic

Frequency not reported: Hypercholesterolemia, hyperuricemia, increased uric acid, increased triglycerides, decreased HDL cholesterol^[Ref]

Hepatic

Postmarketing reports: Abnormal hepatic function (e.g., increased AST, ALT, and bilirubin)^[Ref]

Hypersensitivity

Postmarketing reports: Hypersensitivity (e.g., allergic vasculitis, angioedema, urticaria)^[Ref]