Can vigorous exercise help lower cognitive impairment risk?

Evan Walker
Evan Walker TheMediTary.Com |
older woman rowerShare on Pinterest
Can vigorous exercise help protect brain health in people with hypertension? Image credit: Thomas Barwick/Getty Images.
  • High blood pressure poses several health risks, including a potentially higher risk for cognitive impairment.
  • Researchers are interested in finding what protective factors can help reduce the risk of cognitive problems among individuals with high blood pressure.
  • A recent study suggests that vigorous exercise habits may help decrease the risk of future cognitive impairment.

Impairment of cognitive function can affect all aspects of a person’s life, including quality of life and day-to-day activities.

Multiple factors can contribute to someone’s risk of developing problems in cognitive function, including high blood pressure, or hypertension. Researchers are interested in finding potential protective actions that people with high blood pressure can take.

A new study published in Alzheimer’s & Dementia: The Journal of the Alzheimer’s Association examined the relationship between vigorous physical activity and risk for mild cognitive impairment among people with high blood pressure.

Researchers found that participants who engaged in one or more sessions of vigorous physical activity each week were at a lower risk for mild cognitive impairment and probable dementia.

The results suggest that vigorous exercise may help preserve cognitive function among certain individuals.

The researchers who conducted the current study wanted to evaluate if vigorous exercise helped with the risk for mild cognitive impairment and probable dementia.

This study was a post hoc analysis using data from the SPRINT MIND STUDY, which formed part of the SPRINT trial. This trial involved over 9,000 adults in the United States who had high blood pressure.

At enrolment, participants were asked about the frequency of participating in vigorous physical activity. Vigorous physical activity was defined as activities that induced sweat, increased heart rate, or increased breathing.

Participants could pick their level of vigorous physical activity from the following categories:

  1. rarely or never
  2. one to three vigorous activity sessions a month
  3. one vigorous activity session a week
  4. two to four vigorous activity sessions a week
  5. five or more vigorous activity sessions a week.

In the analysis, researchers divided participants into a low-vigorous physical activity group and a high-vigorous physical activity group.

The low-vigorous physical activity group had less than one vigorous activity session a week, and the high-vigorous physical activity group had one or more vigorous activity sessions a week.

All participants also underwent cognitive assessment tests, and covariates included components like age, education, smoking, use of antihypertensive medication, body mass index (BMI), and alcohol use.

The researchers excluded participants who had limited physical function or missing cognitive assessments, allowing them to include 7,670 participants in their final analysis.

The average follow-up time with participants was 4.5 years, and over this time, there were identified cases of mild cognitive impairment and probable dementia.

Overall, participants in the high vigorous physical activity group were at a lower risk for mild cognitive impairment and probable dementia.

The association was stronger among participants less than 75 years old at baseline, and Black participants. The association also appeared stronger in participants with prior cardiovascular disease.

Despite the intriguing findings, this study does face some specific limitations.

First, some of the data came from participants’ self-reports, which means it can be inaccurate. Then, almost 65% of participants were white, and about 35% were women, indicating the need for greater diversity in future research and a limited ability to generalize the results.

The findings also cannot be generalized to groups with certain conditions not represented in the SPRINT study, such as those with diabetes. The exclusion criteria of the current analysis could also have impacted the results.

The authors further acknowledge that their study “likely lacked the adequate statistical power to detect the benefit of [vigorous physical actvity] on the risk of probable dementia.”

There is also a potential confounding risk, and researchers only looked at baseline data for vigorous physical activity. Changes in vigorous physical activity could have impacted cognitive outcomes.

Moreover, the researchers did not look at how moderate physical activity or the potential negatives of sedentary behavior could affect cognitive status. Finally, mild cognitive impairment “at the time of enrolment was not adjudicated,” which could have impacted the results.

Future research can allow for longer follow-up times to confirm the findings of this research. Kazibwe noted that future research could include “[s]tudies using device-assessed physical activity in large and diverse populations are needed to investigate the benefits of vigorous physical activity for protecting against cognitive decline.”

Share this Article