Cervical cancer: Induction chemotherapy could improve survival by 39%

Evan Walker
Evan Walker TheMediTary.Com |
A close-up of an IV drip depicting induction chemotherapy for cervical cancerShare on Pinterest
Induction chemotherapy could improve survival rates in advanced cervical cancer. Penpak Ngamsathain/Getty Images
  • Recent improvements in cancer survival rates are partly due to improvements in treatments, as well as screening and prevention.
  • Efforts to improve cervical cancer survival have focused on screening for early detection and human papillomavirus (HPV) vaccination for prevention.
  • However, some people do still receive diagnoses of advanced cancer requiring treatment.
  • A recent study has shown that induction therapy could improve overall advanced cervical cancer survival rates by 39%.

Findings for a clinical trial started in 2012 to test the efficacy of induction therapy— a type of first-line chemotherapy treatment—in people with advanced cervical cancer were recently announced at the European Society for Medical Oncology (ESMO) congress on Sunday, October 22, 2023.

The trial results showed that induction therapy improved overall survival rates from advanced cervical cancer by as much as 39%.

The abstract for the INTERLACE phase III trial, funded by Cancer Research UK and UCL Cancer Trials Centre, was published in the Annals of Oncology.

Researchers recruited a cohort of 500 women with cervical cancer that was larger than 4 centimeters (cm) across (stage 1B2 to stage 4A), or 4 cm or less (stage 1B1 if the cancer is also in the lymph nodes) at centres in the U.K., Mexico, India, Italy, and Brazil.

They split this group into two arms, one of which received six weekly doses of carboplatin and paclitaxel chemotherapy before receiving up to 6 weeks of chemotherapy drug cisplatin and radiation therapy for their cancer.

The second arm of the study received just the standard six weeks of chemotherapy and radiation therapy for their cancer.

Lead author Dr Mary McCormack, a consultant clinical oncologist at University College London Hospitals NHS Trust in the U.K., where she is also the senior clinical oncologist in gynecological cancer, ​​told Medical News Today in an interview:

“We wanted to look at this approach. We wanted to see if we get some additional chemotherapy which can attack cancer cells. Will this reduce the risk of the cancer coming back in the lung and in the liver and in the lymph glands of the abdominal area. Will this reduce those risks of relapse?”

Researchers then followed up the cohort for five years, and found that patients who had received the induction chemotherapy had a significantly improved overall survival rate.

Those who had received induction therapy, chemotherapy, and radiotherapy had an overall survival rate at five years of 80%, compared to a 5-year survival rate of 72% of patients who had just the standard chemotherapy and radiotherapy.

This represented a 39% reduction in risk of death over five years in patients who received the induction therapy first.

What does progression-free survival mean?

Progression-free survival describes when people survive without their cancer growing or spreading.

Those who had received induction therapy, chemotherapy, and radiotherapy had a progression-free survival rate at five years of 73%, compared to a five progression-free survival rate of 64% of patients who had just the standard chemotherapy and radiotherapy. This represented a 35% reduction in risk of progression in the five years following treatment.

Side effects were greater in the group who had the induction chemotherapy, with 59% of that group experiencing side effects that interfered with their basic living ability, compared to 48% of the other group.

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