By using this site, you agree to the Privacy Policy and Terms of Use.
Accept
Medical Information, Documents, News - TheMediTary.Com Logo Medical Information, Documents, News - TheMediTary.Com Logo

TheMediTary.Com

Medical Information, Documents, News - TheMediTary.Com

  • Home
  • News
  • Drugs
  • Drugs A-Z
  • Medical Answers
  • About Us
  • Contact
Medical Information, Documents, News - TheMediTary.Com Logo Medical Information, Documents, News - TheMediTary.Com Logo
Search Drugs
  • Drugs
    • Latest Drugs
    • Drugs A-Z
    • Medical Answers
  • News
    • FDA Alerts
    • Medical News
    • Health
    • Consumer Updates
    • Children's Health
  • More TheMediTary.Com
    • About Us
    • Contact
Follow US
Home > Drugs > Digestive enzymes > Cholic acid > Cholic acid Side Effects
Digestive enzymes

Cholic acid Side Effects

Applies to cholic acid: oral capsule.

Serious side effects of Cholic acid

Along with its needed effects, cholic acid may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur while taking cholic acid:

More common

  • Abdominal or stomach pain
  • chills
  • clay-colored stools
  • dark urine
  • diarrhea
  • dizziness
  • fever
  • general feeling of tiredness or weakness
  • headache
  • itching or rash
  • light-colored stools
  • loss of appetite
  • nausea
  • stomach pain, continuing
  • unpleasant breath odor
  • unusual tiredness or weakness
  • vomiting
  • vomiting of blood
  • yellow eyes or skin

Less common

  • Bladder pain
  • bloody or cloudy urine
  • clay-colored stools
  • dark urine
  • difficult, burning, or painful urination
  • frequent urge to urinate
  • lower back or side pain
  • unpleasant breath odor

Other side effects of Cholic acid

Some side effects of cholic acid may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects.

Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

Less common

  • Burning, numbness, tingling, or painful sensations
  • chest pain
  • difficulty with swallowing
  • general feeling of discomfort or illness
  • heartburn
  • pain or burning in the throat
  • skin lesions
  • sores, ulcers, or white spots on the lips or tongue or inside the mouth
  • unsteadiness or awkwardness
  • weakness in the arms, hands, legs, or feet

For Healthcare Professionals

Applies to cholic acid: oral capsule.

General

The most common adverse reactions have included diarrhea, reflux esophagitis, malaise, jaundice, skin lesions, nausea, abdominal pain, intestinal polyp, urinary tract infection, and peripheral neuropathy.[Ref]

Hepatic

Common (1% to 10%): Exacerbation of hepatic impairment including deaths, jaundice

Uncommon (0.1% to 1%): Cholelithiasis

Frequency not reported: Transaminase increased, gallstones[Ref]

Ten patients, five with single enzyme defect (SED) and 5 with peroxisomal disorders (PD) experienced worsening transaminases, elevated bilirubin values, or worsening cholestasis on liver biopsy during treatment. Of these 10 patients, five (3 SED and 2 PD) had liver impairment at baseline while the other 5 did not have baseline cholestasis, but experienced exacerbation of liver disease while on treatment. Exacerbation by this drug could not be ruled out.

Deaths attributed to progression of underlying liver disease were reported in 5 patients aged 1 year or less in trial 1 (SED, n=50; PD, n=29); three patients had AKR1D1 deficiency, 1 had 3beta-HSD and 1 had CYP7A1 deficiency. Of the 29 patients in trial 1 with PDs including Zellweger spectrum disorders, 12 patients aged 7 months to 2.5 years died; 8 of the 12 deaths were attributed to progression of underlying liver disease or a worsening of their primary illness. Two additional deaths in trial 1 were both patients who had been off study medication for more than 1 year; their deaths were most likely due to a progression of their underlying liver disease.

In trial 2 (SED, n=31; PD, n=12) 2 patients with SED died; cause of death was unrelated to their primary treatment or progression of their underlying liver disease. Four patients between the ages of 4 and 8 years with PD died (1 new patient and 3 who rolled over from trial 1); cause of death in 3 of these 4 patients was attributed to progression of underlying liver disease or worsening of their primary illness.

One patient with 3 beta-HSD deficiency developed symptomatic cholelithiasis requiring cholecystectomy.

Gallstones have been reported after long-term therapy.[Ref]

Gastrointestinal

Pruritus and/or persistent diarrhea may be signs of a potential overdose and should be investigated as such.[Ref]

Common (1% to 10%): Diarrhea, reflux esophagitis, nausea, abdominal pain, intestinal polyp[Ref]

Dermatologic

Common (1% to 10%): Skin lesion

Frequency not reported: Pruritus[Ref]

Pruritus and/or persistent diarrhea may be signs of a potential overdose and should be investigated as such.[Ref]

Genitourinary

Common (1% to 10%): Urinary tract infection[Ref]

Nervous system

Common (1% to 10%): Peripheral neuropathy[Ref]

Other

Common (1% to 10%): Malaise[Ref]

Share this Article
Latest News
Medical News

Vitamin D supplements may help slow down aging by 3 years

May 28, 2025
Aging: Exercise timing, consistency can affect heart and lung fitness
Heart health: Exercise not enough to offset effects of poor sleep
Ministrokes may result in 1 year of chronic fatigue
Ulcerative colitis: Strawberry tree extract may aid treatment
Frontotemporal dementia: Protein changes may trigger it in middle age
Related Drugs
Fidanacogene Elaparvovec
Cerave Anti-Itch
Centrum Adult
Crovalimab
Cyltezo Prefilled Syringe
Zepbound Pen
Mylanta One
Uretron Ds
Medihoney Wound And Burn Dressing
Lidotrode

Other drugs

Name Drug Class Updated
Fidanacogene Elaparvovec Drugs 03-Oct-2024
Cerave Anti-Itch Drugs 02-Oct-2024
Centrum Adult Drugs 02-Oct-2024
Crovalimab Drugs 02-Oct-2024
Cyltezo Prefilled Syringe Drugs 01-Oct-2024
Zepbound Pen Drugs 30-Sep-2024
Mylanta One Drugs 27-Sep-2024
Uretron Ds Drugs 27-Sep-2024
Medihoney Wound And Burn Dressing Drugs 26-Sep-2024
Lidotrode Drugs 26-Sep-2024
Libervant Drugs 26-Sep-2024
Moderna Covid-19 Drugs 25-Sep-2024
Beqvez Drugs 24-Sep-2024
Beqvez Drugs 24-Sep-2024
Beqvez Drugs 24-Sep-2024

Categories

  • FDA Alerts
  • Medical News
  • Health
  • Consumer Updates
  • Children's Health

About US

Welcome to TheMediTary.Com

Our website provides reliable and up-to-date information on various medical topics. We empower individuals to take charge of their health by simplifying complex medical jargon and providing practical tips and advice. We prioritize the privacy and confidentiality of our users and welcome feedback to improve our services.

Website use data of FDA and other sources

DMCA.com Protection Status Truste Protection Status Trust Mark Protection Status
HONcode logo We comply with the HONcode standard for trustworthy health information.
Quick Link
  • About Us
  • Contact Us
  • Editorial Policy
  • Privacy Policy
  • Accessibility Policy
  • Terms & Conditions
  • Disclaimer
  • DMCA
  • Do Not Sell My Personal Information
  • Sitemap
  • Care Notes
  • Health Guide
  • Professional
Drugs
  • New Drugs
  • Medical Answers
  • Drugs A-Z
  • Drug Classes
  • Drug Dosage
  • Pill Identifier
  • Consumer Infor
  • Side Effects
  • Inactive Ingredients
  • Pregnancy Warnings
  • Patient Tips
  • Treatments
News
  • Latest News
  • FDA Alerts
  • Medical News
  • Health
  • Consumer Updates
  • Children's Health
Find US
  • Medium
  • Google Site
  • Blogspot
  • API
  • Reddit
  • Tumblr
  • Scoop.it
  • Substack
  • Wordpress
  • Wix
  • Behance

© 2025 TheMediTary.Com All rights reserved. Operated by