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Home > Drugs > Calcimimetics > Cinacalcet > Cinacalcet Side Effects
Calcimimetics

Cinacalcet Side Effects

Summary

Commonly reported side effects of cinacalcet include: decreased plasma testosterone, diarrhea, dizziness, myalgia, nausea, vomiting, and hypoparathyroidism. Other side effects include: dialysis access infection, asthenia, chest pain, hypertension, hypotension, and anorexia. Continue reading for a comprehensive list of adverse effects.

Applies to cinacalcet: oral tablets.

Side effects include:

Dialysis patients with secondary hyperparathyroidism: Nausea, vomiting, diarrhea, myalgia, dyspnea, cough, hypotension, headache, hypocalcemia, muscle spasms, abdominal pain (including upper abdominal pain), dizziness, hyperkalemia, upper respiratory tract infection, dyspepsia, hypertension, asthenia, anorexia/decreased appetite, noncardiac chest pain, access infection, constipation.

Patients with hypercalcemia associated with parathyroid carcinoma or primary hyperparathyroidism: Adverse effects generally similar to those observed in dialysis patients.

For Healthcare Professionals

Applies to cinacalcet: oral tablet.

Cardiovascular

Very common (10% or more): Hypotension (11.6%)

Common (1% to 10%): Hypertension

Frequency not reported: Worsening heart failure, QT prolongation and ventricular arrhythmia secondary to hypocalcemia[Ref]

Gastrointestinal

Very common (10% or more): Nausea (31%), vomiting (27%), diarrhea (21%), dyspepsia (13%), abdominal pain (10.9%)

Common (1% to 10%): Upper abdominal pain, dyspepsia, anorexia, constipation[Ref]

Hypersensitivity

Common (1% to 10%): Hypersensitivity reactions

Postmarketing reports: Rash, angioedema, urticaria[Ref]

Local

Common (1% to 10%): Access site infection[Ref]

Dermatologic

Very common (10% or more): Paresthesia (14 to 29%)

Very rare (less than 0.01%): Leukocytoclastic vasculitis with palpable purpura on both upper and lower extremities[Ref]

Hematologic

Common (1% to 10%): Anemia[Ref]

Metabolic

Very common (10% or more): Hypocalcemia (11.2%)

Common (1% to 10%): Hyperkalemia, dehydration[Ref]

Respiratory

Very common (10% or more): Cough (11.7%), upper respiratory infection (11%)

Common (1% to 10%): Dyspnea[Ref]

Endocrine

Common (1% to 10%): Reduced testosterone levels[Ref]

Musculoskeletal

Very common (10% or more): Myalgia (15%), muscle spasms (11%)

Common (1% to 10%): Limb pain, back pain, fracture, arthralgia, noncardiac chest pain[Ref]

Nervous system

Very common (10% or more): Paresthesia (up to 29%), headache (11.5%), dizziness (10%)

Common (1% to 10%): Fatigue, seizures[Ref]

Other

Common (1% to 10%): Asthenia[Ref]

Renal

Common (1% to 10%): Dialysis access site infection[Ref]

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