By using this site, you agree to the Privacy Policy and Terms of Use.
Accept
Medical Information, Documents, News - TheMediTary.Com Logo Medical Information, Documents, News - TheMediTary.Com Logo

TheMediTary.Com

Medical Information, Documents, News - TheMediTary.Com

  • Home
  • News
  • Drugs
  • Drugs A-Z
  • Medical Answers
  • About Us
  • Contact
Medical Information, Documents, News - TheMediTary.Com Logo Medical Information, Documents, News - TheMediTary.Com Logo
Search Drugs
  • Drugs
    • Latest Drugs
    • Drugs A-Z
    • Medical Answers
  • News
    • FDA Alerts
    • Medical News
    • Health
    • Consumer Updates
    • Children's Health
  • More TheMediTary.Com
    • About Us
    • Contact
Follow US
Home > Drugs > Antiadrenergic agents, centrally acting > Clonidine (injection) > Clonidine (injection) Side Effects
Antiadrenergic agents, centrally acting

Clonidine Side Effects

Summary

Commonly reported side effects of clonidine include: drowsiness, fatigue, hypotension, lethargy, sedated state, headache, and upper abdominal pain. Other side effects include: dizziness. Continue reading for a comprehensive list of adverse effects.

Applies to clonidine: oral tablet, oral tablet extended release. Other dosage forms:

  • epidural solution
  • transdermal patch extended release

Serious side effects of Clonidine

Along with its needed effects, clonidine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur while taking clonidine:

Less common

  • Mental depression
  • swelling of the feet and lower legs

Rare

  • Anxiety
  • blistering, burning, crusting, dryness, or flaking of the skin
  • chest pain or discomfort
  • confusion as to time, place, or person
  • decreased urine output
  • dilated neck veins
  • drowsiness
  • dry mouth
  • fast, pounding, or irregular heartbeat or pulse
  • fever
  • general feeling of discomfort or illness
  • holding false beliefs that cannot be changed by fact
  • hyperventilation
  • irregular breathing
  • irritability
  • itching, scaling, severe redness, soreness, or swelling of the skin
  • large, hive-like swelling on the face, eyelids, lips, tongue, throat, hands, legs, feet, or sex organs
  • lightheadedness, dizziness, or fainting
  • mental depression
  • paleness or cold feeling in the fingertips and toes
  • pounding, slow heartbeat
  • problems in urination or increase in the amount of urine
  • raised red swellings on the skin, lips, tongue, or in the throat
  • restlessness
  • seeing or hearing things that are not there
  • shaking
  • shortness of breath
  • skin rash
  • swelling of the face, fingers, feet, or lower legs
  • tightness in the chest
  • tingling or pain in the fingers or toes when exposed to cold
  • trouble with sleeping
  • troubled breathing
  • unusual excitement, nervousness, or restlessness
  • unusual tiredness or weakness
  • vivid dreams or nightmares
  • weight gain
  • wheezing

Get emergency help immediately if any of the following symptoms of overdose occur while taking clonidine:

Symptoms of overdose

  • Dizziness (extreme) or faintness
  • feeling cold
  • pinpoint pupils of the eyes
  • unusual tiredness or weakness (extreme)

Other side effects of Clonidine

Some side effects of clonidine may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects.

Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common

  • Constipation

Less common

  • Darkening of the skin
  • decreased sexual ability
  • dry, itching, or burning eyes
  • loss of appetite
  • nausea or vomiting

Rare

  • Blurred vision
  • decreased interest in sexual intercourse
  • hair loss or thinning of the hair
  • inability to have or keep an erection
  • leg cramps
  • loss in sexual ability, desire, drive, or performance
  • muscle or joint pain
  • pale skin
  • swelling of the breasts or breast soreness in both females and males
  • weakness

For Healthcare Professionals

Applies to clonidine: compounding powder, injectable solution, oral suspension extended release, oral tablet, oral tablet extended release, transdermal film extended release.

Cardiovascular

Very common (10% or more): Hypotension (45%), orthostatic hypotension (32%)

Common (1% to 10%): Chest pain, tachycardia

Uncommon (0.1% to 1%): Sinus bradycardia, Raynaud's phenomenon, palpitations

Rare (0.01% to 0.1%): Atrioventricular block, palpitations, bradycardia, syncope, congestive heart failure, electrocardiographic abnormalities (i.e., sinus node arrest, high degree AV block), cerebrovascular accident

Frequency not reported: Bradyarrhythmia, hypertension, rebound hypertension[Ref]

Dermatologic

Very common (10% or more): Contact dermatitis with the patch formulation (19%)

Common (1% to 10%): Sweating

Uncommon (0.1% to 1%): Pruritus, rash (localized or generalized), urticaria, erythema

Rare (0.01% to 0.1%): Alopecia, excoriation, burning

Very rare (less than 0.01%): Papules, throbbing, blanching, generalized macular rash, facial/tongue angioedema

Frequency not reported: Hives, localized hypo or hyper pigmentation[Ref]

Endocrine

Rare (0.01% to 0.1%): Gynecomastia[Ref]

Gastrointestinal

Very common (10% or more): Dry mouth (40%), upper abdominal pain (15%), nausea (13%), vomiting (10%)

Common (1% to 10%): Constipation, parotid gland pain

Uncommon (0.1% to 1%): Colonic pseudo-obstruction

Very rare (less than 0.01%): Parotitis[Ref]

Genitourinary

Common (1% to 10%): Erectile dysfunction

Frequency not reported: Micturition difficulty, loss of libido, decreased sexual activity, nocturia, urinary retention[Ref]

General

Most adverse effects are mild and diminish with continued therapy. The most frequent (which appear to be dose-related) are dry mouth (40%), drowsiness (33%), dizziness (16%), constipation (10%), and sedation (10%).[Ref]

Hematologic

Rare (0.01% to 0.1%): Peripheral blood flow disturbance, thrombocytopenia[Ref]

Hepatic

Frequency not reported: Mild transient abnormalities of liver function tests, hepatitis[Ref]

Metabolic

Rare (0.01% to 0.1%): Blood glucose increased, serum creatine phosphokinase increased

Frequency not reported: Weight gain, anorexia[Ref]

Musculoskeletal

Frequency not reported: Muscle pain, joint pain, leg cramps[Ref]

Nervous system

Very common (10% or more): Drowsiness (33%), dizziness (16%), somnolence (13%), sedation (10%)

Common (1% to 10%): Headache

Uncommon (0.1% to 1%): Paresthesia

Frequency not reported: Headache, localized numbness[Ref]

Ocular

Rare (0.01% to 0.1%): Lacrimation decreased (dry eyes)

Frequency not reported: Accommodation disorder, ocular burning, vision blurred[Ref]

Other

Common (1% to 10%): Fatigue, tinnitus

Uncommon (0.1% to 1%): Malaise

Frequency not reported: Fever, pallor, weakness, positive Coombs' test, increased sensitivity to alcohol[Ref]

Psychiatric

Very common (10% or more): Confusion (13%)

Common (1% to 10%): Depression, tearfulness, sleep disorder, hallucinations (both visual and auditory), nervousness, agitation

Uncommon (0.1% to 1%):

Rare (0.01% to 0.1%): Delusional perception, nightmare

Frequency not reported: Libido decreased, restlessness, anxiety, irritability, behavior changes[Ref]

Respiratory

Common (1% to 10%): Hypoventilation

Rare (0.01% to 0.1%): Nasal dryness[Ref]

Share this Article
Latest News
Medical News

Shingles vaccine may lower heart disease risk by up to 8 years

May 09, 2025
Obesity, unhealthy lifestyles may cause heart to age by 5–45 years
Aging: As little as 5 minutes of exercise may keep the brain healthy
Prostate cancer: Simple urine test may help with early detection
Cancer treatment side effects: Exercise may reduce pain, fatigue
Alzheimer's: Exercising in middle age may reduce beta-amyloid in brain...
Related Drugs
Fidanacogene Elaparvovec
Cerave Anti-Itch
Centrum Adult
Crovalimab
Cyltezo Prefilled Syringe
Zepbound Pen
Mylanta One
Uretron Ds
Medihoney Wound And Burn Dressing
Lidotrode

Other drugs

Name Drug Class Updated
Fidanacogene Elaparvovec Drugs 03-Oct-2024
Cerave Anti-Itch Drugs 02-Oct-2024
Centrum Adult Drugs 02-Oct-2024
Crovalimab Drugs 02-Oct-2024
Cyltezo Prefilled Syringe Drugs 01-Oct-2024
Zepbound Pen Drugs 30-Sep-2024
Mylanta One Drugs 27-Sep-2024
Uretron Ds Drugs 27-Sep-2024
Medihoney Wound And Burn Dressing Drugs 26-Sep-2024
Lidotrode Drugs 26-Sep-2024
Libervant Drugs 26-Sep-2024
Moderna Covid-19 Drugs 25-Sep-2024
Beqvez Drugs 24-Sep-2024
Beqvez Drugs 24-Sep-2024
Beqvez Drugs 24-Sep-2024

Categories

  • FDA Alerts
  • Medical News
  • Health
  • Consumer Updates
  • Children's Health

About US

Welcome to TheMediTary.Com

Our website provides reliable and up-to-date information on various medical topics. We empower individuals to take charge of their health by simplifying complex medical jargon and providing practical tips and advice. We prioritize the privacy and confidentiality of our users and welcome feedback to improve our services.

Website use data of FDA and other sources

DMCA.com Protection Status Truste Protection Status Trust Mark Protection Status
HONcode logo We comply with the HONcode standard for trustworthy health information.
Quick Link
  • About Us
  • Contact Us
  • Editorial Policy
  • Privacy Policy
  • Accessibility Policy
  • Terms & Conditions
  • Disclaimer
  • DMCA
  • Do Not Sell My Personal Information
  • Sitemap
  • Care Notes
  • Health Guide
  • Professional
Drugs
  • New Drugs
  • Medical Answers
  • Drugs A-Z
  • Drug Classes
  • Drug Dosage
  • Pill Identifier
  • Consumer Infor
  • Side Effects
  • Inactive Ingredients
  • Pregnancy Warnings
  • Patient Tips
  • Treatments
News
  • Latest News
  • FDA Alerts
  • Medical News
  • Health
  • Consumer Updates
  • Children's Health
Find US
  • Medium
  • Google Site
  • Blogspot
  • API
  • Reddit
  • Tumblr
  • Scoop.it
  • Substack
  • Wordpress
  • Wix
  • Behance

© 2025 TheMediTary.Com All rights reserved. Operated by