Note: This document contains side effect information about bendroflumethiazide / nadolol. Some dosage forms listed on this page may not apply to the brand name Corzide 40/5.
Applies to bendroflumethiazide / nadolol: oral tablet.
Warning
Oral route (Tablet)
Following abrupt cessation of therapy with certain beta-blocking agents, exacerbations of angina pectoris and, in some cases, myocardial infarction have occurred. The dosage should be gradually reduced over 1 to 2 weeks, and the patient should be carefully monitored when discontinuing chronic therapy, particularly in patients with ischemic heart disease. If angina markedly worsens or acute coronary insufficiency develops, nadolol should be reinstated promptly, at least temporarily, and other measures appropriate for the management of unstable angina should be taken. Patients should be warned against interruption or discontinuation of therapy without the physician's advice.
Serious side effects of Corzide 40/5
Along with its needed effects, bendroflumethiazide/nadolol may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.
Check with your doctor immediately if any of the following side effects occur while taking bendroflumethiazide / nadolol:
Less common
- Blurred vision
- burning, crawling, itching, numbness, prickling, "pins and needles", or tingling feelings
- chest pain, tightness, or discomfort
- confusion
- cough
- difficulty breathing
- dilated neck veins
- dizziness, faintness, or lightheadedness when getting up suddenly from a lying or sitting position
- irregular breathing
- lightheadedness, dizziness, or fainting
- noisy breathing
- paleness or cold feeling in fingertips and toes
- slow or irregular heartbeat
- slurred speech
- sweating
- swelling of face, fingers, feet, or lower legs
- tingling or pain in fingers or toes when exposed to cold
- unusual tiredness or weakness
- weight gain
Incidence not known
- Back or leg pains
- black, tarry stools
- bleeding gums
- bloating
- blood in urine or stools
- chills
- clay-colored stools
- cloudy urine
- cold sweats
- constipation
- coughing up blood
- dark urine
- difficulty swallowing
- drowsiness
- dry mouth
- fast heartbeat
- fever
- flushed, dry skin
- fruit-like breath odor
- general body swelling
- general feeling of discomfort or illness
- general tiredness and weakness
- headache
- hives, skin rash
- hoarseness
- increased hunger
- increased thirst
- increased urination
- indigestion
- joint pain, stiffness, or swelling
- light-colored stools
- loss of appetite
- lower back or side pain
- muscle tremors
- nausea and vomiting
- nosebleeds
- pain in the muscles
- painful or difficult urination
- pains in stomach, side, or abdomen, possibly radiating to the back
- pale skin
- pinpoint red spots on the skin
- puffiness or swelling of the eyelids or around the eyes, face, lips, or tongue
- rapid, deep breathing
- redness, soreness, or itching skin
- restlessness
- sore throat
- sores, ulcers, or white spots on the lips or in the mouth
- sores, welting, or blisters
- stomach cramps
- sugar in the urine
- swollen or painful glands
- tenderness of salivary glands
- thickening of bronchial secretions
- trouble breathing
- unpleasant breath odor
- unusual bleeding or bruising
- unusual weight loss
- upper right stomach pain
- vomiting of blood
- yellow eyes or skin
Get emergency help immediately if any of the following symptoms of overdose occur while taking bendroflumethiazide / nadolol:
Symptoms of overdose
- Change in consciousness
- decreased urination
- diarrhea
- fast, slow, or shallow breathing
- gas
- heartburn
- increase in heart rate
- increased sweating
- indigestion
- loss of consciousness
- low blood pressure
- muscle cramps
- numbness, tingling, pain, or weakness in the hands or feet
- pale or blue lips, fingernails, or skin
- seizures
- sunken eyes
- trembling
- unusual drowsiness, dullness, or feeling of sluggishness
- unusual paleness
- weakness and heaviness of the legs
- wrinkled skin
Other side effects of Corzide 40/5
Some side effects of bendroflumethiazide / nadolol may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects.
Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:
Less common
- Change in behavior
- continuing ringing or buzzing or other unexplained noise in the ears
- decreased interest in sexual intercourse
- dry eyes or skin
- excess air or gas in stomach or intestines
- hair loss, thinning of hair
- hearing loss
- inability to have or keep an erection
- loss in sexual ability, desire, drive, or performance
- relaxed and calm
- sleepiness
- stomach soreness or discomfort
- stuffy nose
- weight loss
Incidence not known
- Cracks in the skin
- discoloration of skin
- feeling of constant movement of self or surroundings
- increased sensitivity of skin to sunlight
- large, flat, blue or purplish patches in the skin
- loss of heat from the body
- muscle spasm, weakness, or restlessness
- scaly skin
- sensation of spinning
- severe sunburn
For Healthcare Professionals
Applies to bendroflumethiazide / nadolol: oral tablet.
Cardiovascular
Bendroflumethiazide:
Frequency not reported: Necrotizing angiitis, vasculitis, orthostatic hypotension
Nadolol:
Common (1% to 10%): Heart rate less than 40 beats per minute (bpm), symptoms of peripheral vascular insufficiency, cardiac failure, hypotension, rhythm/conduction disturbances
Frequency not reported: Heart rate less than 60 bpm, first degree heart block, third degree heart block[Ref]
Nervous system
Bendroflumethiazide:
Frequency not reported: Dizziness, vertigo, paresthesia, headache
Nadolol:
Common (1% to 10%): Dizziness/fatigue
Uncommon (0.1% to 1%): Paresthesias, sedation, headache, tinnitus, slurred speech[Ref]
Gastrointestinal
Bendroflumethiazide:
Frequency not reported: Nausea, vomiting, cramping, diarrhea, constipation, gastric irritation, abdominal bloating, sialadenitis, pancreatitis
Nadolol:
Uncommon (0.1% to 1%): Nausea, diarrhea, abdominal discomfort, constipation, vomiting, indigestion, bloating, flatulence, dry mouth[Ref]
Dermatologic
Bendroflumethiazide:
Frequency not reported: Purpura, exfoliative dermatitis, pruritus, ecchymosis, urticaria, cutaneous vasculitis, photosensitivity, rash
Nadolol:
Uncommon (0.1% to 1%): Rash, pruritus, dry skin, sweating, facial swelling
Frequency not reported: Reversible alopecia[Ref]
Respiratory
Bendroflumethiazide:
Frequency not reported: Respiratory distress, pneumonitis
Nadolol:
Uncommon (0.1% to 1%): Bronchospasm, cough, nasal stuffiness[Ref]
Metabolic
Bendroflumethiazide:
Frequency not reported: Anorexia, hyperglycemia, metabolic acidosis, hyperuricemia
Nadolol:
Uncommon (0.1% to 1%): Anorexia, weight gain[Ref]
Ocular
Bendroflumethiazide:
Frequency not reported: Xanthopsia, transient blurred vision
Nadolol:
Uncommon (0.1% to 1%): Dry eyes, blurred vision[Ref]
Psychiatric
Bendroflumethiazide:
Frequency not reported: Restlessness
Nadolol:
Uncommon (0.1% to 1%): Change in behavior, impotence or decreased libido[Ref]
Hematologic
Bendroflumethiazide:
Frequency not reported: Leukopenia, agranulocytosis, thrombocytopenia, hemolytic anemia, aplastic anemia[Ref]
Hepatic
Bendroflumethiazide:
Frequency not reported: Intrahepatic cholestatic jaundice, hepatitis[Ref]
Immunologic
Bendroflumethiazide:
Frequency not reported: Anaphylactic reactions, allergic glomerulonephritis[Ref]
Other
Bendroflumethiazide:
Frequency not reported: Fever, weakness[Ref]
Genitourinary
Bendroflumethiazide:
Frequency not reported: Glycosuria[Ref]
Musculoskeletal
Bendroflumethiazide:
Frequency not reported: Muscle spasm[Ref]
