Applies to cytomegalovirus immune globulin: parenteral injection for iv infusion.

Side effects include:

Flushing, chills, muscle cramps, back pain, fever, nausea, vomiting, arthralgia, wheezing/shortness of breath/chest tightness.

For Healthcare Professionals

Applies to cytomegalovirus immune globulin: intravenous solution.

General

The most common adverse events were flushing, chills, muscle cramps, back pain, fever, nausea, vomiting, arthralgia, and wheezing. Such reactions are most often related to infusion rates.^[Ref]

Renal

Frequency not reported: Increases in serum creatinine, increase in blood urea nitrogen (BUN), acute renal failure, acute tubular necrosis, proximal tubular nephropathy, osmotic nephrosis^[Ref]

Cardiovascular

Uncommon (0.1% to 1%): Decrease in blood pressure

Frequency not reported: Flushing

Postmarketing reports: Cardiac arrest, thromboembolism, vascular collapse, hypotension^[Ref]

Dermatologic

Postmarketing reports: Stevens-Johnson syndrome, epidermolysis, erythema multiforme, bullous dermatitis^[Ref]

Gastrointestinal

Frequency not reported: Nausea, vomiting

Postmarketing reports: Abdominal pain^[Ref]

Hematologic

Postmarketing reports: Pancytopenia, leukopenia, hemolysis, positive direct antiglobulin (Coombs) test^[Ref]

Hepatic

Postmarketing reports: Hepatic dysfunction^[Ref]

Musculoskeletal

Frequency not reported: Chills, muscle cramps, back pain, arthralgia^[Ref]

Nervous system

Postmarketing reports: Coma, loss of consciousness, seizures, tremor^[Ref]

Respiratory

Frequency not reported: Wheezing

Postmarketing reports: Apnea, acute respiratory distress syndrome (ARDS), transfusion related acute lung injury (TRALI), cyanosis, hypoxemia, pulmonary edema, dyspnea, bronchospasm^[Ref]

Other

Postmarketing reports: Fever, rigors^[Ref]

Genitourinary

Frequency not reported: Oliguria, anuria requiring dialysis