Summary

Commonly reported side effects of dalfampridine include: urinary tract infection. Other side effects include: balance impairment, insomnia, and nausea. Continue reading for a comprehensive list of adverse effects.

Applies to dalfampridine: oral tablet extended release.

Serious side effects of Dalfampridine

Along with its needed effects, dalfampridine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur while taking dalfampridine:

More common

• Bladder pain
• bloody or cloudy urine
• difficult, burning, or painful urination
• frequent urge to urinate
• lower back or side pain

Less common

• Blurred vision
• burning, crawling, itching, numbness, prickling, "pins and needles", or tingling feelings
• difficulty controlling your bladder or bowels
• feeling sad or depressed
• forgetful
• muscle cramps
• problems with swallowing
• slurred speech
• unusual tiredness or weakness

Incidence not known

• Chest tightness
• cough
• dizziness or lightheadedness
• fast heartbeat
• feeling of constant movement of self or surroundings
• hives, itching, skin rash
• puffiness or swelling of the eyelids or around the eyes, face, lips, or tongue
• sensation of spinning
• vomiting

Get emergency help immediately if any of the following symptoms of overdose occur while taking dalfampridine:

Symptoms of overdose

• Confusion
• increased sweating
• memory loss
• reduced awareness
• seizures
• weakness

Other side effects of Dalfampridine

Some side effects of dalfampridine may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects.

Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common

• Headache
• lack or loss of strength
• nausea
• problems with balance
• trouble sleeping

Less common

• Back pain
• constipation
• fever
• muscle aches
• sore throat
• stomach discomfort, upset, or pain
• stuffy or runny nose

For Healthcare Professionals

Applies to dalfampridine: oral tablet extended release.

Nervous system

Common (1% to 10%): Dizziness, headache, balance disorder, multiple sclerosis relapse, paresthesia, tremor

Uncommon (0.1% to 1%): Seizure, exacerbation of trigeminal neuralgia^[Ref]

Gastrointestinal

Common (1% to 10%): Nausea, constipation, dyspepsia

Postmarketing reports: Vomiting^[Ref]

Musculoskeletal

Common (1% to 10%): Back pain^[Ref]

Respiratory

Common (1% to 10%): Nasopharyngitis, pharyngolaryngeal pain, dyspnea^[Ref]

Genitourinary

Very common (10% or more): Urinary tract infection (12%)^[Ref]

Hypersensitivity

Uncommon (0.1% to 1%): Anaphylaxis, angioedema, hypersensitivity^[Ref]

Psychiatric

Common (1% to 10%): Insomnia, anxiety^[Ref]

Other

Common (1% to 10%): Asthenia

Uncommon (0.1% to 1%): Chest discomfort^[Ref]

Cardiovascular

Common (1% to 10%): Palpitations^[Ref]

Dermatologic

Uncommon (0.1% to 1%): Rash, urticaria^[Ref]