Applies to diazoxide: oral suspension.

Side effects include:

Sodium and fluid retention, tachycardia, palpitations, increased uric acid concentrations, hyperglycemia or glycosuria, GI intolerance, hirsutism, thrombocytopenia.

For Healthcare Professionals

Applies to diazoxide: compounding powder, injectable solution, oral capsule, oral suspension.

Cardiovascular

Angina with myocardial and cerebral infarction have been associated with the use of a 300 mg intravenous dose of diazoxide.

One case of optic nerve infarction was reported following a single 300 mg bolus dose of diazoxide, as a result of a sudden reduction in diastolic pressure.

Results from one prospective trial conducted in patients with severe hypertension and coronary artery disease showed a 50% incidence of ischemic changes in the electrocardiogram following single 300 mg bolus injections of diazoxide.^[Ref]

Common (1% to 10%): Tachycardia, palpitations

Frequency not reported: Hypotension, transient hypertension, chest pain^[Ref]

Nervous system

Frequency not reported: Transient loss of taste, headache, dizziness, polyneuritis, paresthesia, extrapyramidal signs^[Ref]

Gastrointestinal

Frequency not reported: Nausea, vomiting, abdominal pain, ileus, diarrhea^[Ref]

Metabolic

Sodium and fluid retention may precipitate congestive heart failure in patients with compromised cardiac reserve.^[Ref]

Common (1% to 10%): Increased levels of serum uric acid

Frequency not reported: Sodium retention, fluid retention, diabetic ketoacidosis, hyperosmolar nonketotic coma, hyperglycemia, glycosuria, anorexia^[Ref]

Respiratory

Frequency not reported: Pulmonary hypertension^[Ref]

Other

Frequency not reported: Weakness, malaise, fever^[Ref]

Hematologic

Frequency not reported: Thrombocytopenia with or without purpura, neutropenia, eosinophilia, decreased hemoglobin/hematocrit, excessive bleeding, azotemia, lymphadenopathy^[Ref]

Immunologic

Frequency not reported: Decreased IgG, monilial dermatitis, herpes^[Ref]

Musculoskeletal

Frequency not reported: Advance in bone age^[Ref]

Ocular

Frequency not reported: Transient cataracts, subconjunctival hemorrhage, ring scotoma, blurred vision, diplopia, lacrimation^[Ref]

Psychiatric

Frequency not reported: Anxiety, insomnia^[Ref]

Genitourinary

Frequency not reported: Decreased urinary output, hematuria, albuminuria, galactorrhea, enlargement of lump in breast^[Ref]

Hepatic

Frequency not reported: Increased AST, increased alkaline phosphatase^[Ref]

Renal

Frequency not reported: Decreased creatinine clearance, reversible nephrotic syndrome^[Ref]

Dermatologic

Frequency not reported: Hirsutism of lanugo type (mainly on the forehead, back, and limbs), skin rash, pruritus, loss of scalp hair^[Ref]

Endocrine

Frequency not reported: Gout, acute pancreatitis/pancreatic necrosis^[Ref]