Applies to dopamine: parenteral injection concentrate for iv infusion, parenteral injection for iv infusion.
Warning
Special Alerts:
A standardized concentration for this drug has been established through Standardize 4 Safety (S4S), a national patient safety initiative to reduce medication errors, especially during transitions of care. The drug is included in a standard concentration list which may apply to an IV or oral compounded liquid formulation. For additional information, see the ASHP website [Web].
Side effects include:
Dopamine may cause cardiac conduction abnormalities (e.g., ventricular arrhythmia, atrial fibrillation, widened QRS complex, ectopic heartbeats), tachycardia, angina, palpitation, bradycardia, vasoconstriction, hypotension, hypertension, dyspnea, nausea, vomiting, headache, anxiety, azotemia, piloerection, and gangrene of the extremities.
For Healthcare Professionals
Applies to dopamine: intravenous solution.
Cardiovascular
Common (1% to 10%): Ectopic beats, tachycardia, anginal pain, palpitation, hypotension, vasoconstriction
Uncommon (0.1% to 1%): Aberrant ventricular conduction/ventricular arrhythmia, bradycardia, widened QRS complex, hypertension
Frequency not reported: Gangrene of the feet/extremities, peripheral cyanosis, fatal ventricular arrhythmias, atrial fibrillation, cardiac conduction abnormalities[Ref]
Gangrene of the feet occurred in patients with preexisting vascular disorders and/or at doses of at least 10 to 14 mcg/kg/min given for prolonged periods of time.
Ventricular arrhythmias occurred at very high doses.[Ref]
Gastrointestinal
Common (1% to 10%): Nausea, vomiting[Ref]
Nervous system
Common (1% to 10%): Headache[Ref]
Respiratory
Common (1% to 10%): Dyspnea[Ref]
Dermatologic
Very rare (less than 0.01%): Gangrene
Frequency not reported: Piloerection[Ref]
Local
Frequency not reported: Necrosis, tissue sloughing, local ischemia and vasoconstriction[Ref]
Necrosis and tissue sloughing may be caused by extravasation of this drug.[Ref]
Psychiatric
Frequency not reported: Anxiety[Ref]
Renal
Frequency not reported: Azotemia[Ref]
Ocular
Frequency not reported: Mydriasis[Ref]
Metabolic
Frequency not reported: Hypovolemia[Ref]
