Drug Class: Upper respiratory combinations
Usual Adult Dose for Cold Symptoms
**Many different strength combinations and dosage forms are available. The manufacturer product information should be consulted.**
Acetaminophen 325 mg/ diphenhydramine 12.5 mg/ phenylephrine 5 mg per caplet: 2 caplets every 4 hours
Maximum dose: 5 doses (10 caplets) per 24 hours
Acetaminophen 325 mg/ diphenhydramine 25 mg/ phenylephrine 5 mg per 15 mL liquid: 30 mL every 4 hours
Maximum dose: 6 doses per 24 hours
Acetaminophen 500 mg/ diphenhydramine 25 mg/ phenylephrine 10 mg per packet: One packet every 4 hours
Maximum dose: 6 doses per 24 hours
Acetaminophen 650 mg/ diphenhydramine 25 mg/ phenylephrine 10 mg per pod/packet: One pod/packet every 4 hours
Maximum dose: 5 doses per 24 hours
Acetaminophen 650 mg/ diphenhydramine 25 mg/ phenylephrine 10 mg per 20 mL: 20 mL every 4 hours
Maximum dose: 6 doses per 24 hours
Acetaminophen 650 mg/ diphenhydramine 25 mg/ phenylephrine 10 mg per 30 mL: 30 mL every 4 hours
Maximum dose: 5 doses per 24 hours
Usual Pediatric Dose for Cold Symptoms
**Many different strength combinations and dosage forms are available. The manufacturer product information should be consulted.**
Acetaminophen 325 mg/ diphenhydramine 12.5 mg/ phenylephrine 5 mg per caplet:
12 years and older: 2 caplets every 4 hours
Maximum dose: 5 doses (10 caplets) per 24 hours
Acetaminophen 325 mg/ diphenhydramine 25 mg/ phenylephrine 5 mg per 15 mL liquid:
12 years and older: 30 mL every 4 hours
Maximum dose: 6 doses per 24 hours
Acetaminophen 500 mg/ diphenhydramine 25 mg/ phenylephrine 10 mg per packet:
12 years and older: One packet every 4 hours
Maximum dose: 6 doses per 24 hours
Acetaminophen 650 mg/ diphenhydramine 25 mg/ phenylephrine 10 mg per pod/packet:
12 years and older: One pod/packet every 4 hours
Maximum dose: 5 doses per 24 hours
Acetaminophen 650 mg/ diphenhydramine 25 mg/ phenylephrine 10 mg per 20 mL:
12 years and older: 20 mL every 4 hours
Maximum dose: 6 doses per 24 hours
Acetaminophen 650 mg/ diphenhydramine 25 mg/ phenylephrine 10 mg per 30 mL:
12 years and older: 30 mL every 4 hours
Maximum dose: 5 doses per 24 hours
Renal Dose Adjustments
Data not available
Liver Dose Adjustments
Use with caution.
Precautions
CONTRAINDICATIONS:
- Hypersensitivity to acetaminophen.
- Current use of any other drug containing acetaminophen.
- Current use of a monoamine oxidase inhibitor (MAOI) or use within 14 days of stopping a MAOI.
- Current use of any other drug containing diphenhydramine, including topical preparations.
Safety and efficacy have not been established in patients younger than 12 years.
Consult WARNINGS section for additional precautions.
Dialysis
Data not available
Other Comments
Administration advice:
- The manufacturer product information should be consulted for reconstitution instructions.
Patient advice:
- This product contains acetaminophen; severe liver damage may occur with use of over 4000 mg in 24 hours, use with other acetaminophen-containing medications, or having 3 or more alcoholic drinks a day during use.
- Do not use with any other drug containing acetaminophen.
- Avoid drinking alcohol while on this drug.
- Use caution if driving a motor vehicle or operating machinery.
- If cough comes back, or is accompanied or followed by fever, headache that lasts, or rash, seek medical care promptly.
- Discontinue for cough, pain, or nasal congestion that worsens or lasts over 7 days, if new symptoms arise, fever worsens or lasts over 3 days, or for redness or swelling.
- PHENYLKETONURICS: Some formulations contain phenylalanine; the manufacturer product information should be consulted.
