Usual Adult Dose for Cold Symptoms

Acetaminophen 325 mg/ pheniramine 20 mg/ phenylephrine 10 mg packets: 1 packet in water every 4 hours
Maximum dose: 3 packets per 24 hours

Acetaminophen 650 mg/ pheniramine 20 mg/ phenylephrine 10 mg packets: 1 packet in water every 4 hours
Maximum dose: 5 packets per 24 hours

Usual Pediatric Dose for Cold Symptoms

Acetaminophen 325 mg/ pheniramine 20 mg/ phenylephrine 10 mg packets:
12 years and older: 1 packet in water every 4 hours
Maximum dose: 3 packets per 24 hours

Acetaminophen 650 mg/ pheniramine 20 mg/ phenylephrine 10 mg packets:
12 years and older: 1 packet in water every 4 hours
Maximum dose: 5 packets per 24 hours

Renal Dose Adjustments

Use with caution in severe renal disease.

Liver Dose Adjustments

Use with caution in severe hepatic disease.

Precautions

CONTRAINDICATIONS:

• Hypersensitivity to any of the ingredients
• Current use of any other drug containing acetaminophen.
• Current use of a monoamine oxidase inhibitor (MAOI) or use within 14 days of stopping a MAOI.
• Use with caution in marked coronary atherosclerosis, arterial hypertension, narrow-angle glaucoma, severe hepatic or renal disease, prostatic hyperplasia, blood diseases, glucose-6-phosphate dehydrogenase deficiency, congenital hyperbilirubinemia (Gilbert, Dubin-Johnson, and Rotor syndromes), hyperthyroidism, pheochromocytoma, and bronchial asthma.

Dialysis

Data not available

Other Comments

Administration advice:

• Dissolve packets in 8 ounces hot water; sip while hot and consume entire drink within 10 to 15 minutes
• If microwaving, add packet to 8 ounces cold water; stir briskly before and after heating; do not overheat.
• May add sugar to taste.

• Do not use more than directed.
• Avoid alcoholic drinks.
• Keep out of reach of children.
• Drowsiness may occur; concomitant sedatives or tranquilizer may increase drowsiness.
• Discontinue for nervousness, dizziness, or sleepiness.
• Use caution if driving a motor vehicle or operating machinery.