5HT3 receptor antagonists
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Aloxi Dosage

Drug Detail:Aloxi (Palonosetron (injection) [ pal-oh-noe-se-tron ])

Generic Name: PALONOSETRON HYDROCHLORIDE 0.05mg in 1mL

Dosage Form: injection

Drug Class: 5HT3 receptor antagonists

Contents
Uses Warnings Before Taking Dosage Side effects Interactions

Recommended Dosage

Prevention of Chemotherapy-Induced Nausea and Vomiting

The recommended dosage of ALOXI injection for prevention of nausea and vomiting associated with HEC and MEC in adults and associated with emetogenic chemotherapy, including HEC in pediatric patients 1 month to less than 17 years of age is shown in Table 1.

Table 1: Recommended Dosage of ALOXI Injection for the Prevention of Nausea and Vomiting Associated with Chemotherapy in Adults and Pediatric Patients 1 Month to Less than 17 Years
*
Note different dosing units in pediatrics
Age Dose * Infusion Time
Adults 0.25 mg as a single dose Infuse over 30 seconds beginning approximately 30 minutes before the start of chemotherapy
Pediatrics
(1 month to less than 17 years)		 20 micrograms per kilogram (max 1.5 mg) as a single dose Infuse over 15 minutes beginning approximately 30 minutes before the start of chemotherapy

Postoperative Nausea and Vomiting

The recommended dosage of ALOXI injection in adults for PONV is 0.075 mg administered as a single intravenous dose over 10 seconds immediately before the induction of anesthesia.

Instructions for Intravenous Administration

  • ALOXI injection is supplied ready for intravenous administration at a concentration of 0.05 mg/mL (50 mcg/mL).
  • Do not mix ALOXI injection with other drugs.
  • Flush the infusion line with normal saline before and after administration of ALOXI injection.
  • Inspect ALOXI injection visually for particulate matter and discoloration before administration.
  • Discard unused portion.
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