Chloride channel activators
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Amitiza Dosage

Drug Detail:Amitiza (Lubiprostone [ loo-bee-pros-tone ])

Generic Name: lubiprostone 8ug

Dosage Form: capsule, gelatin coated

Drug Class: Chloride channel activators

Contents
Uses Warnings Before Taking Dosage Side effects Interactions FAQ

Recommended Dosage

The recommended oral dosage of Amitiza by indication and adjustments for patients with moderate (Child Pugh Class B) and severe (Child Pugh Class C) hepatic impairment are shown in Table 1.

Table 1. Recommended Dosage Regimen
CIC and OIC IBS-C
*
If the dose is tolerated and an adequate response has not been obtained after an appropriate interval, doses can then be escalated to full dosing with appropriate monitoring of patient response.
Recommended Adult Dosage Regimen 24 mcg twice daily 8 mcg twice daily
Dosage Adjustment for Hepatic Impairment [see Use in Specific Populations (8.6)] Moderate Impairment (Child-Pugh Class B):
16 mcg twice daily*		 Moderate Impairment (Child-Pugh Class B):
No adjustment necessary
Severe Impairment (Child-Pugh Class C):
8 mcg twice daily*		 Severe Impairment (Child-Pugh Class C):
8 mcg once daily*

Administration Instructions

  • Take Amitiza orally with food and water.
  • Swallow capsules whole and do not break apart or chew.
  • Physicians and patients should periodically assess the need for continued therapy.
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