Usual Adult Dose for Erectile Dysfunction

Initial dose: 100 mg orally as needed approximately 30 minutes before sexual activity.
Maintenance dose: 50 to 200 mg orally as needed 30 minutes before sexual activity.
Maximum dose: 200 mg orally once a day

Comments:

• The lowest dose that provides benefit should be taken.
• Sexual stimulation is needed for a response to treatment.

Renal Dose Adjustments

• Mild to Moderate Renal Dysfunction (creatinine clearance greater than or equal to 30 and less than 90 mL/min): No adjustment recommended
• Severe Renal Dysfunction: Not recommended

Liver Dose Adjustments

• Mild to Moderate Liver Dysfunction (Child-Pugh A or B): No adjustment recommended
• Severe Liver Dysfunction: Not recommended

Dose Adjustments

In patients on stable alpha-blocker therapy, the recommended starting dose is 50 mg.

Precautions

Safety and efficacy have not been established in patients younger than 18 years.

Consult WARNINGS section for additional precautions.

Dialysis

Data not available.

Other Comments

Administration advice: Avanafil can be taken with or without food