Drug Detail:Bicalutamide (Bicalutamide [ bye-ka-loo-ta-mide ])
Drug Class: Antiandrogens Hormones / antineoplastics
Usual Adult Dose for Prostate Cancer
In combination with an LHRH analog: 50 mg orally once a day (morning or evening)
Comments:
- Therapy with this drug should be started at the same time as therapy with an LHRH analog.
- If a dose is missed, take the next dose at the scheduled time. Do not take the missed dose and do not double the next dose.
Use: For use in combination therapy with a luteinizing hormone-releasing hormone (LHRH) analog for the treatment of Stage D2 metastatic carcinoma of the prostate
Renal Dose Adjustments
No adjustment recommended.
Liver Dose Adjustments
Mild hepatic impairment: No adjustment recommended.
Moderate to severe hepatic impairment: Caution recommended.
Precautions
CONTRAINDICATIONS:
- Hypersensitivity to the active component or any of the ingredients
- Females
- Pregnancy
Safety and efficacy have not been established in patients younger than 18 years.
Consult WARNINGS section for additional precautions.
Dialysis
This drug is highly protein bound; therefore, it is not removed by dialysis.
Other Comments
Administration advice:
- This drug may be taken with or without food.
- Take this drug at the same time each day.
Storage requirements:
- Store tablets at controlled room temperature, 20C to 25C (68F to 77F).
General:
- This drug is not approved for use alone or with other therapies at 150 mg daily.
Patient advice:
- Read the approved patient labeling each time you fill this medication.
- This drug and the LHRH analog should be started at the same time and not interrupted or stopped without consulting your healthcare provider.
- Your healthcare provider should monitor your liver function regularly during therapy to detect signs of hepatitis.
- Notify your healthcare provider of any bleeding or spontaneous bruising while taking this drug with anticoagulants.
- This drug can cause drowsiness. See how it affects you before driving or operating machinery.
- This drug can cause photosensitivity. Avoid direct exposure to excessive sunlight or UV-light exposure. Consider using sunscreen.