Usual Adult Dose for Ascites

Oral: 0.5 to 2 mg once a day.
IV or IM: 0.5 to 1 mg once.
Continuous IV infusion: 1 mg/hour up to 12 mg/day.

Usual Adult Dose for Edema

Oral: 0.5 to 2 mg once a day.
IV or IM: 0.5 to 1 mg once.
Continuous IV infusion: 1 mg/hour up to 12 mg/day.

Usual Adult Dose for Pulmonary Edema

Oral: 0.5 to 2 mg once a day.
IV or IM: 0.5 to 1 mg once.
Continuous IV infusion: 1 mg/hour up to 12 mg/day.

Renal Dose Adjustments

Data not available

Liver Dose Adjustments

Patients with cirrhosis and ascites should be given smaller doses of bumetanide due to the risk of altered electrolyte balance, which can lead to hepatic encephalopathy.

Dose Adjustments

Oral doses may be titrated every 4 hours.
IV doses may be titrated every 2 to 3 hours.
Patients with edema often benefit from alternate day or every 3 to 4 day therapy.
Patients with liver disease and renal dysfunction should have dose adjustments made cautiously.

Precautions

US BOXED WARNING:

• FLUID AND ELECTROLYTE DEPLETION: This drug is a potent diuretic which, if given in excessive amounts, can lead to a profound diuresis with water and electrolyte depletion. Therefore, careful medical supervision is required, and dose and dosage schedule have to be adjusted to the individual patient's needs.

Dialysis

Data not available

Other Comments

The maximum recommended dose is 10 mg/day or 12 mg/12 hours continuous IV infusion.

Frequently asked questions

• What are the equivalent dosages of bumetanide, furosemide & torsemide?