Usual Adult Dose for Anxiety

• Initial Dose: 7.5 mg orally 2 times a day
• Maintenance Dose: Dosage may be increased 5 mg per day at intervals of 2 to 3 days, as needed.
• Maximum Dose: 60 mg per day

Renal Dose Adjustments

• Mild to Moderate Renal Impairment: Dose adjustments may be required; however, no specific guidelines have been suggested. Caution is recommended.
• Severe Renal Impairment: Not recommended.

Liver Dose Adjustments

• Mild to Moderate Hepatic Impairment: Dose adjustments may be required; however, no specific guidelines have been suggested. Caution is recommended.
• Severe Hepatic Impairment: Not recommended.

Precautions

Safety and efficacy have not been established in patients younger than 18 years.

Consult WARNINGS section for additional precautions.

Dialysis

Data not available.

Other Comments

Administration Advice:

• This drug should be taken at the same time each day, and consistently with or without food.
• The usual therapeutic dosage is 15 to 30 mg per day given in divided doses; the dosage should be individualized for each patient.
• The usefulness of this drug should be periodically reassessed if used for extended periods.

• The effectiveness of this drug for more than 3 to 4 weeks has not been demonstrated.
• Overdosage: There is no specific antidote.
• Anxiolytic agents like this drug are not typically used to treat anxiety or tension associated with the stress of everyday life.

• Avoid drinking or ingesting any grapefruit products.
• Avoid driving and other potentially dangerous activities such as operating machinery until you know how this drug affects you.