Dosage

The recommended dosage of CANASA in adults is 1000 mg administered rectally once daily at bedtime for 3 to 6 weeks depending on symptoms and sigmoidoscopic findings. Safety and effectiveness of CANASA beyond 6 weeks have not been established.

Administration Instructions:

• Evaluate renal function prior to initiation of CANASA therapy [see Warnings and Precautions (5.1)].
  
• Do not cut or break the suppository.
  
• Retain the suppository for one to three hours or longer, if possible.
  
• Drink an adequate amount of fluids [see Warnings and Precautions (5.7)]
  
• If a dose of CANASA is missed, administer as soon as possible, unless it is almost time for next dose. Do not use two CANASA suppositories at the same time to make up for a missed dose.
  
• CANASA suppositories will cause staining of direct contact surfaces, including but not limited to fabrics, flooring, painted surfaces, marble, granite, vinyl, and enamel. Keep CANASA away from these surfaces to prevent staining.