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Home > Drugs > Next generation cephalosporins > Ceftaroline > Ceftaroline Dosage
Next generation cephalosporins
https://themeditary.com/dosage-information/ceftaroline-dosage-10053.html

Ceftaroline Dosage

Drug Detail:Ceftaroline (Ceftaroline [ sef-ta-roe-leen ])

Drug Class: Next generation cephalosporins

Contents
Uses Warnings Before Taking Dosage Side effects Interactions

Usual Adult Dose for Pneumonia

600 mg IV every 12 hours

Duration of therapy:

  • Acute bacterial skin and skin structure infections (ABSSSI): 5 to 14 days
  • Community-acquired bacterial pneumonia (CABP): 5 to 7 days

Uses:
  • For the treatment of ABSSSI due to susceptible isolates of Staphylococcus aureus (including methicillin-susceptible and -resistant isolates), Streptococcus pyogenes, S agalactiae, Escherichia coli, Klebsiella pneumoniae, and K oxytoca
  • For the treatment of CABP due to susceptible isolates of S pneumoniae (including cases with concurrent bacteremia), S aureus (methicillin-susceptible isolates only), Haemophilus influenzae, K pneumoniae, K oxytoca, and E coli

Usual Adult Dose for Skin and Structure Infection

600 mg IV every 12 hours

Duration of therapy:

  • Acute bacterial skin and skin structure infections (ABSSSI): 5 to 14 days
  • Community-acquired bacterial pneumonia (CABP): 5 to 7 days

Uses:
  • For the treatment of ABSSSI due to susceptible isolates of Staphylococcus aureus (including methicillin-susceptible and -resistant isolates), Streptococcus pyogenes, S agalactiae, Escherichia coli, Klebsiella pneumoniae, and K oxytoca
  • For the treatment of CABP due to susceptible isolates of S pneumoniae (including cases with concurrent bacteremia), S aureus (methicillin-susceptible isolates only), Haemophilus influenzae, K pneumoniae, K oxytoca, and E coli

Usual Pediatric Dose for Skin and Structure Infection

Less than 2 months (gestational age at least 34 weeks and postnatal age at least 12 days): 6 mg/kg IV every 8 hours
2 months to less than 2 years: 8 mg/kg IV every 8 hours
2 years to less than 18 years (up to 33 kg): 12 mg/kg IV every 8 hours
2 years to less than 18 years (greater than 33 kg): 400 mg IV every 8 hours OR 600 mg IV every 12 hours

Duration of therapy: 5 to 14 days

Comments:

  • Drug levels in cerebrospinal fluid have not been evaluated in pediatric patients younger than 2 months.
  • No information available for dosing this drug in infants less than 34 weeks gestational age and younger than 12 days postnatal age.

Use: For the treatment of ABSSSI due to susceptible isolates of S aureus (including methicillin-susceptible and -resistant isolates), S pyogenes, S agalactiae, E coli, K pneumoniae, and K oxytoca

Usual Pediatric Dose for Pneumonia

2 months to less than 2 years: 8 mg/kg IV every 8 hours
2 years to less than 18 years (up to 33 kg): 12 mg/kg IV every 8 hours
2 years to less than 18 years (greater than 33 kg): 400 mg IV every 8 hours OR 600 mg IV every 12 hours

Duration of therapy: 5 to 14 days

Use: For the treatment of CABP due to susceptible isolates of S pneumoniae (including cases with concurrent bacteremia), S aureus (methicillin-susceptible isolates only), H influenzae, K pneumoniae, K oxytoca, and E coli

Renal Dose Adjustments

Adults:

  • Estimated CrCl greater than 50 mL/min: No adjustment recommended.
  • Estimated CrCl greater than 30 to 50 mL/min: 400 mg IV every 12 hours
  • Estimated CrCl 15 to 30 mL/min: 300 mg IV every 12 hours
  • ESRD (CrCl less than 15 mL/min): 200 mg IV every 12 hours

Pediatrics:
  • CrCl greater than 50 mL/min/1.73 m2: No adjustment recommended.
  • CrCl less than 50 mL/min/1.73 m2: Data not available

Comments:
  • Adults: CrCl estimated using the Cockcroft-Gault formula.
  • Pediatrics: CrCl estimated using the Schwartz equation.

Liver Dose Adjustments

Data not available

Precautions

CONTRAINDICATIONS:
Known serious hypersensitivity to the active component or other cephalosporins

ABSSSI: Safety and efficacy have not been established in patients less than 34 weeks gestational age and younger than 12 days postnatal age.
CABP: Safety and efficacy have not been established in patients younger than 2 months.

Consult WARNINGS section for additional precautions.

Dialysis

Adults:

  • Hemodialysis: 200 mg IV every 12 hours

Pediatrics: Data not available

Comments:
  • Because this drug is hemodialyzable, it should be administered after hemodialysis on hemodialysis days.

Other Comments

Administration advice:

  • Administer via IV infusion over 5 to 60 minutes in adults and pediatric patients at least 2 months of age; administer via IV infusion over 30 to 60 minutes in pediatric patients younger than 2 months.
  • Therapy duration should be guided by severity and site of infection and by patient's clinical and bacteriological progress.

Storage requirements:
  • Unreconstituted vials: Store at 25C (77F); excursions permitted to 15C to 30C (59F to 86F).
  • Constituted solution in Baxter Mini-Bag Plus: Store solutions (concentration range: 4 to 12 mg/mL) for up to 6 hours at room temperature or for up to 24 hours at 2C to 8C (36F to 46F).
  • Constituted solution in infusion bag: Use within 6 hours when stored at room temperature or within 24 hours when stored at 2C to 8C (36F to 46F).

Reconstitution/preparation techniques:
  • After constitution, further dilution is required; final volume for infusion into patients should be between 50 to 250 mL.
  • The manufacturer product information should be consulted.

IV compatibility:
  • Compatible: Sterile water for injection; 0.9% sodium chloride injection; 5% dextrose injection; 2.5% dextrose injection; 0.45% sodium chloride injection; lactated ringer's injection
  • Compatibility with other drugs not established; should not mix with or physically add to solutions containing other drugs.

General:
  • To reduce the development of drug-resistant organisms and maintain effective therapy, this drug should be used only to treat or prevent infections proven or strongly suspected to be caused by susceptible bacteria.
  • Appropriate specimens for microbiological testing recommended before therapy to isolate and identify infecting organisms and to establish susceptibility to this drug.
  • Culture and susceptibility information should be considered when selecting/modifying antibacterial therapy or, if no data are available, local epidemiology and susceptibility patterns may be considered when selecting empiric therapy.

Patient advice:
  • Avoid missing doses and complete the entire course of therapy.
  • Contact healthcare provider if severe watery or bloody diarrhea occurs.
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