Sex hormone combinations
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Climara Pro Dosage

Drug Detail:Climara pro (Estradiol and levonorgestrel (transdermal) [ ess-tra-dy-ol-and-lee-vo-nor-jess-trell ])

Generic Name: ESTRADIOL 0.045mg in 1d, LEVONORGESTREL 0.015mg in 1d

Dosage Form: patch

Drug Class: Sex hormone combinations

Contents
Uses Warnings Before Taking Dosage Side effects Interactions

Use estrogen-alone, or in combination with a progestogen, at the lowest effective dose and for the shortest duration consistent with treatment goals and risks for the individual women. Reevaluate postmenopausal women periodically as clinically appropriate to determine if treatment is still necessary.

One Climara Pro transdermal system is available for use.

Treatment of Moderate to Severe Vasomotor Symptoms due to Menopause

Start therapy with Climara Pro 0.045 mg per day/0.015 mg per day applied to the skin once weekly. Start therapy at the lowest effective dose and the shortest duration consistent with the treatment goals. Attempts to discontinue Climara Pro should be made at 3 to 6 month intervals.

Prevention of Postmenopausal Osteoporosis

Apply Climara Pro 0.045 mg per day/0.015 mg per day applied to the skin once weekly.

Application of the Climara Pro Transdermal System

Initiation of Therapy

Women not currently using continuous estrogen-alone therapy or estrogen plus progestogen therapy may start therapy with Climara Pro at any time. However, women currently using continuous estrogen-alone therapy or estrogen plus progestogen therapy should complete the current cycle of therapy before initiating Climara Pro therapy. Women often experience withdrawal bleeding at the completion of the cycle. The first day of this bleeding would be an appropriate time to begin Climara Pro therapy.

Site Selection

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Place the adhesive side of Climara Pro on a smooth (fold free), clean, dry area of the skin on the lower abdomen or the upper quadrant of the buttock.
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Do not apply Climara Pro to or near the breasts.
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Select an area selected that is not oily (which can impair adherence of the system), damaged, or irritated.
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Avoid the waistline; tight clothing may rub Climara Pro off or modify drug delivery.
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Avoid application to areas where sitting would dislodge Climara Pro.
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Rotate the sites of application, with an interval of at least 1-week allowed between applications to the same site.

Application

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Apply Climara Pro immediately after opening the pouch and removing the protective lining.
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Press Climara Pro firmly in place with the fingers for at least 10 seconds, making sure there is good contact, especially around the edges.
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If the system lifts, apply pressure to maintain adhesion.
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In the event that a system should fall off, reapply the same system to another area of the lower abdomen. If the system cannot be reapplied, a new system may be applied, in which case, the original treatment schedule should be continued.
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Only one system should be worn at any one time during 7-day dosing interval.
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Do not expose the applied transdermal system to the sun for prolonged periods of time.
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Swimming, bathing, or using a sauna while using Climara Pro has not been studied, and these activities may decrease the adhesion of the system and the delivery of the estrogen and progestin.

Removal of the Climara Pro Transdermal System

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Remove Climara Pro carefully and slowly to avoid irritation of the skin.
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If any adhesive remain on the skin after removal of Climara Pro, allow the area to dry for 15 minutes and then gently rub the area with an oil-based cream or lotion should remove the adhesive residue.
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Used patches still contain some active hormones. Carefully fold each patch in half so that it sticks to itself before throwing it away.
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