Drug Detail:Dextroamphetamine (Dextroamphetamine [ dex-tro-am-fet-a-meen ])
Drug Class: CNS stimulants
Usual Adult Dose for Narcolepsy
- Initial Dose: 10 mg orally per day
- Maintenance Dose: May raise daily dose in 10 mg increments at weekly intervals until optimal response is obtained.
Comments:
- The usual dose is 5 to 60 mg per day in divided doses, depending on the individual patient response.
- IR: Give the first dose on awakening; give 1 to 2 additional doses at intervals of 4 to 6 hours.
- ER/SR: May use this formulation for once-a-day dosage wherever appropriate.
Use: Narcolepsy treatment
Usual Pediatric Dose for Attention Deficit Disorder
Immediate-Release (IR):
Age 3 to 5 Years:
- Initial Dose: 2.5 mg orally per day
- Maintenance Dose: May raise daily dose in 2.5 mg increments at weekly intervals until optimal response is obtained.
IR and Extended-Release (ER)/Sustained-Release (SR):
Age 6 to 17 Years:
- Initial Dose: 5 mg orally 1 or 2 times a day
- Maintenance Dose: May raise daily dose in 5 mg increments at weekly intervals until optimal response is obtained.
- Maximum Dose: Only in rare cases will it be necessary to exceed 40 mg per day.
Comments:
- IR: Give the first dose on awakening; give 1 to 2 additional doses at intervals of 4 to 6 hours.
- ER/SR: May use this formulation for once-a-day dosage wherever appropriate.
- Where possible, occasionally interrupt drug administration to determine if continued therapy is required.
Use: As part of a total treatment program for Attention Deficit Hyperactivity Disorder (ADHD).
Usual Pediatric Dose for Narcolepsy
Age 6 to 11 Years:
- Initial Dose: 5 mg orally per day
- Maintenance Dose: May raise daily dose in 5 mg increments at weekly intervals until optimal response is obtained.
Age 12 Years and Older:
- Initial Dose: 10 mg orally per day
- Maintenance Dose: May raise daily dose in 10 mg increments at weekly intervals until optimal response is obtained.
Comments:
- The usual dose is 5 to 60 mg per day in divided doses, depending on the individual patient response.
- IR: Give the first dose on awakening; give 1 to 2 additional doses at intervals of 4 to 6 hours.
- ER/SR: May use this formulation for once-a-day dosage wherever appropriate.
- Narcolepsy rarely occurs in children under 12 years of age.
Use: Narcolepsy treatment
Renal Dose Adjustments
Data not available.
Liver Dose Adjustments
Data not available.
Dose Adjustments
Narcolepsy Patients: Reduce dosage if bothersome adverse reactions (e.g., insomnia, anorexia) appear.
Precautions
US BOXED WARNINGS:
- Due to the high abuse potential, this drug should be prescribed/dispensed sparingly and particular attention should be paid to subjects possibly obtaining this drug for non-therapeutic use or distribution to others.
- Administering this drug for prolonged periods of time should be avoided as it may lead to drug dependence.
- Drug misuse may cause sudden death and serious cardiovascular adverse events.
Long-term effects of amphetamines in children have not been well established.
- For ADHD treatment, the IR formulations are not recommended in patients younger than 3 years and the ER/SR formulation is not recommended in patients younger than 6 years.
- For narcolepsy treatment, all formulations of this drug are not recommended in patients younger than 6 years.
Consult WARNINGS section for additional precautions.
US Controlled Substance: Schedule II
Dialysis
Data not available.
Other Comments
Administration Advice:
- Avoid late evening doses because of the potential for insomnia.
- Administer this drug at the lowest effective dosage, and individually adjust dosage.
- Take tablet doses at the same times on each day preferably with or immediately after meals.
Storage Requirements:
- Store this drug between 20 to 25 degrees Celsius (68 to 77 Fahrenheit) and dispense in a tight, light-resistant container.
General:
- Individual patient response to amphetamines varies widely: toxic symptoms can occur at doses as low as 2 mg but are rare with doses of less than 15 mg; 30 mg can produce severe reactions yet doses of 400 to 500 mg are not necessarily fatal.
- Overdosage: Management is largely symptomatic and may include gastric lavage, activated charcoal, a cathartic, and sedation; insufficient data is available to recommend the use of hemodialysis or peritoneal dialysis.
Monitoring:
- Cardiovascular: Blood pressure, heart rate, changes in fingers and toes
- General: Signs of abuse/dependence
- Musculoskeletal: Growth (height, weight, appetite)
- Psychiatric: New or worsening psychiatric disorders, including aggressive behavior/hostility, depression, psychosis, mania, and suicidal thoughts or behavior
Patient Advice:
- Avoid driving and other potentially dangerous activities such as operating machinery until you know how this drug affects you.
- Contact your healthcare provider if you experience any of the following on your fingers or toes during treatment: unexplained wounds, new numbness, pain, skin color change, or temperature sensitivity.
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