Usual Adult Dose for Hypoglycemia

Initial dose: 3 mg/kg per day divided into three equal doses every 8 hours
Usual dose: 3 to 8 mg/kg orally, divided into two or three equal doses every 8 or 12 hours

Comments:

• Use only after confirmed diagnosis of hypoglycemia due to one of the listed conditions.
• Use only if specific medical therapy or surgical management has been unsuccessful or is not feasible.
• Observe patients closely during treatment initiation.
• Carefully monitor clinical response and blood glucose until the patient has stabilized, usually several days.
• Discontinue if no efficacy after two to three weeks use.
• Individualize dose based on clinical and laboratory effects with the least amount of drug.

Usual Pediatric Dose for Hypoglycemia

Infants and newborns:
Initial dose: 10 mg/kg/day divided into three equal doses every 8 hours
Usual dose: 8 to 15 mg/kg/day divided into two or three equal doses every 8 or 12 hours

Children:
Initial dose: 3 mg/kg per day divided into three equal doses every 8 hours
Usual dose: 3 to 8 mg/kg orally, divided into two or three equal doses every 8 or 12 hours

Comments:

• Use only after confirmed diagnosis of hypoglycemia due to one of the listed conditions.
• Use only if specific medical therapy or surgical management has been unsuccessful or is not feasible.
• Observe patients closely during treatment initiation.
• Carefully monitor clinical response and blood glucose until the patient has stabilized, usually several days.
• Discontinue if no efficacy after two to three weeks use.
• Individualize dose based on clinical and laboratory effects with the least amount of drug.
• Use special care to assure accurate dosing in infants and young children.

• Hypoglycemia due to hyperinsulinism associated with leucine sensitivity, islet cell hyperplasia, nesidioblastosis, extrapancreatic malignancy, islet cell adenoma, or adenomatosis
• May be used preoperatively as a temporary measure, or postoperatively if hypoglycemia persists

Renal Dose Adjustments

Dose adjustment(s) may be required; however, no specific guidelines have been suggested. Caution is recommended.

Liver Dose Adjustments

Data not available

Precautions

CONTRAINDICATIONS:

• Use for functional hypoglycemia
• Hypersensitivity to diazoxide or other thiazides, unless benefits outweigh risks

Dialysis

Data not available

Frequently asked questions

• Should you use a diuretic with diazoxide?
• How does diazoxide (Proglycem) cause hyperglycemia?
• Is diazoxide a vasodilator?
• How does diazoxide slow insulin?