Usual Adult Dose for Diphtheria Prophylaxis

ADACEL(R):
10 to 64 years old: 0.5 mL intramuscularly once

• Routine booster vaccination should be 5 or more years after the last recommended dose of the diphtheria, tetanus, and acellular pertussis vaccine adsorbed (DTaP) series.
• May use as a booster dose 8 years after the first tetanus toxoid, reduced diphtheria and acellular pertussis vaccine, adsorbed (Tdap) dose.
• May use for tetanus prophylaxis in wound management if at least 5 years have elapsed since a previous tetanus toxoid containing vaccine dose.

BOOSTRIX(R): 0.5 mL intramuscularly once

• Administer 5 years after the last recommended dose of the DTaP series.
• There are no data to support repeat administration of BOOSTRIX(R), or for its use for primary immunization.
• May use for tetanus prophylaxis in wound management if no previous dose of any Tdap has been given.

Uses:

• Booster immunization after completion of primary diphtheria, tetanus, and acellular pertussis vaccine adsorbed (DTaP) vaccine series.
• Tetanus prophylaxis in wound management.

Usual Adult Dose for Pertussis Prophylaxis

ADACEL(R):
10 to 64 years old: 0.5 mL intramuscularly once

• Routine booster vaccination should be 5 or more years after the last recommended dose of the diphtheria, tetanus, and acellular pertussis vaccine adsorbed (DTaP) series.
• May use as a booster dose 8 years after the first tetanus toxoid, reduced diphtheria and acellular pertussis vaccine, adsorbed (Tdap) dose.
• May use for tetanus prophylaxis in wound management if at least 5 years have elapsed since a previous tetanus toxoid containing vaccine dose.

BOOSTRIX(R): 0.5 mL intramuscularly once

• Administer 5 years after the last recommended dose of the DTaP series.
• There are no data to support repeat administration of BOOSTRIX(R), or for its use for primary immunization.
• May use for tetanus prophylaxis in wound management if no previous dose of any Tdap has been given.

Uses:

• Booster immunization after completion of primary diphtheria, tetanus, and acellular pertussis vaccine adsorbed (DTaP) vaccine series.
• Tetanus prophylaxis in wound management.

Usual Adult Dose for Tetanus Prophylaxis

ADACEL(R):
10 to 64 years old: 0.5 mL intramuscularly once

• Routine booster vaccination should be 5 or more years after the last recommended dose of the diphtheria, tetanus, and acellular pertussis vaccine adsorbed (DTaP) series.
• May use as a booster dose 8 years after the first tetanus toxoid, reduced diphtheria and acellular pertussis vaccine, adsorbed (Tdap) dose.
• May use for tetanus prophylaxis in wound management if at least 5 years have elapsed since a previous tetanus toxoid containing vaccine dose.

BOOSTRIX(R): 0.5 mL intramuscularly once

• Administer 5 years after the last recommended dose of the DTaP series.
• There are no data to support repeat administration of BOOSTRIX(R), or for its use for primary immunization.
• May use for tetanus prophylaxis in wound management if no previous dose of any Tdap has been given.

Uses:

• Booster immunization after completion of primary diphtheria, tetanus, and acellular pertussis vaccine adsorbed (DTaP) vaccine series.
• Tetanus prophylaxis in wound management.

Usual Pediatric Dose for Diphtheria Prophylaxis

ADACEL(R):
10 to 64 years old: 0.5 mL intramuscularly once

• Routine booster vaccination should be 5 or more years after the last recommended dose of the diphtheria, tetanus, and acellular pertussis vaccine adsorbed (DTaP) series.
• May use as a booster dose 8 years after the first tetanus toxoid, reduced diphtheria and acellular pertussis vaccine, adsorbed (Tdap) dose.
• May use for tetanus prophylaxis in wound management if at least 5 years have elapsed since a previous tetanus toxoid containing vaccine dose.

BOOSTRIX(R):
10 years and older: 0.5 mL intramuscularly once

• Administer 5 years after the last recommended dose of the DTaP series.
• There are no data to support repeat administration of BOOSTRIX(R), or for its use for primary immunization.
• May use for tetanus prophylaxis in wound management if no previous dose of any Tdap has been given.

Uses:

• Booster immunization after completion of primary diphtheria, tetanus, and acellular pertussis vaccine adsorbed (DTaP) vaccine series.
• Tetanus prophylaxis in wound management.

Usual Pediatric Dose for Pertussis Prophylaxis

ADACEL(R):
10 to 64 years old: 0.5 mL intramuscularly once

• Routine booster vaccination should be 5 or more years after the last recommended dose of the diphtheria, tetanus, and acellular pertussis vaccine adsorbed (DTaP) series.
• May use as a booster dose 8 years after the first tetanus toxoid, reduced diphtheria and acellular pertussis vaccine, adsorbed (Tdap) dose.
• May use for tetanus prophylaxis in wound management if at least 5 years have elapsed since a previous tetanus toxoid containing vaccine dose.

BOOSTRIX(R):
10 years and older: 0.5 mL intramuscularly once

• Administer 5 years after the last recommended dose of the DTaP series.
• There are no data to support repeat administration of BOOSTRIX(R), or for its use for primary immunization.
• May use for tetanus prophylaxis in wound management if no previous dose of any Tdap has been given.

Uses:

• Booster immunization after completion of primary diphtheria, tetanus, and acellular pertussis vaccine adsorbed (DTaP) vaccine series.
• Tetanus prophylaxis in wound management.

Usual Pediatric Dose for Tetanus Prophylaxis

ADACEL(R):
10 to 64 years old: 0.5 mL intramuscularly once

• Routine booster vaccination should be 5 or more years after the last recommended dose of the diphtheria, tetanus, and acellular pertussis vaccine adsorbed (DTaP) series.
• May use as a booster dose 8 years after the first tetanus toxoid, reduced diphtheria and acellular pertussis vaccine, adsorbed (Tdap) dose.
• May use for tetanus prophylaxis in wound management if at least 5 years have elapsed since a previous tetanus toxoid containing vaccine dose.

BOOSTRIX(R):
10 years and older: 0.5 mL intramuscularly once

• Administer 5 years after the last recommended dose of the DTaP series.
• There are no data to support repeat administration of BOOSTRIX(R), or for its use for primary immunization.
• May use for tetanus prophylaxis in wound management if no previous dose of any Tdap has been given.

Uses:

• Booster immunization after completion of primary diphtheria, tetanus, and acellular pertussis vaccine adsorbed (DTaP) vaccine series.
• Tetanus prophylaxis in wound management.

Renal Dose Adjustments

Data not available

Liver Dose Adjustments

Data not available

Precautions

CONTRAINDICATIONS:

• Severe allergic reaction to any of the ingredients
• Encephalopathy (e.g. coma, decreased consciousness level, prolonged seizures) within 7 day of a previous pertussis containing vaccine

Safety and efficacy have not been established in patients younger than 10 years.

To report suspected adverse reactions, contact the Vaccine Adverse Event Reporting System (VAERS) at: https://vaers.hhs.gov

Consult WARNINGS section for additional precautions.

Dialysis

Data not available

Other Comments

Administration advice:

• For intramuscular administration only.
• Do not administer intravenously, intradermally, or subcutaneously.

Storage requirements:

• Refrigerate; do not freeze.

Reconstitution/preparation techniques:

• Just before use, shake well to form a uniform, white, cloudy suspension.
• Do not use if resuspension does not occur with vigorous shaking.
• Do not use if precipitates or discoloration are present.

IV compatibility:

• Do not mix with other vaccines or medical products.

Patient advice:

• Give patients Vaccine Information Statements prior to administration, as required by the National Childhood Vaccine Injury Act of 1986. These materials are available free of charge at www.cdc.gov/vaccines.