Usual Adult Dose for Intraocular Hypertension

One drop in the affected eye(s) three times a day

Comments:

• This drug may be used concomitantly with other topical ophthalmic drug products to lower intraocular pressure.
• If more than one topical ophthalmic drug is being used, the drugs should be administered at least 5 minutes apart.

Use: Treatment of elevated intraocular pressure in patients with ocular hypertension or open-angle glaucoma

Usual Adult Dose for Glaucoma (Open Angle)

One drop in the affected eye(s) three times a day

Comments:

• This drug may be used concomitantly with other topical ophthalmic drug products to lower intraocular pressure.
• If more than one topical ophthalmic drug is being used, the drugs should be administered at least 5 minutes apart.

Use: Treatment of elevated intraocular pressure in patients with ocular hypertension or open-angle glaucoma

Usual Pediatric Dose for Intraocular Hypertension

Safety and effectiveness have been demonstrated in pediatric patients in a 3-month, multicenter, double-masked, active-treatment-controlled trial:
One drop in the affected eye(s) three times a day

Comments:

• This drug may be used concomitantly with other topical ophthalmic drug products to lower intraocular pressure.
• If more than one topical ophthalmic drug is being used, the drugs should be administered at least 5 minutes apart.

Use: Treatment of elevated intraocular pressure in patients with ocular hypertension or open-angle glaucoma

Usual Pediatric Dose for Glaucoma (Open Angle)

Safety and effectiveness have been demonstrated in pediatric patients in a 3-month, multicenter, double-masked, active-treatment-controlled trial:
One drop in the affected eye(s) three times a day

Comments:

• This drug may be used concomitantly with other topical ophthalmic drug products to lower intraocular pressure.
• If more than one topical ophthalmic drug is being used, the drugs should be administered at least 5 minutes apart.

Use: Treatment of elevated intraocular pressure in patients with ocular hypertension or open-angle glaucoma

Renal Dose Adjustments

Severe renal impairment (CrCl less than 30 mL/min): Not recommended

Liver Dose Adjustments

Hepatic impairment: Use with caution

Precautions

Consult WARNINGS section for additional precautions.

Dialysis

Data not available

Other Comments

Patient advice:

• Patients should be instructed to wash their hands before use and avoid allowing the tip of the bottle to come into contact with the eye or surrounding structures.
• Systemic absorption of drugs from ophthalmic solutions may be minimized by applying

pressure on the tear-duct immediately after application.

• Storage requirements:

Protect from light