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Home > Drugs > Miscellaneous antiemetics > Doxylamine and pyridoxine > Doxylamine / Pyridoxine Dosage
Miscellaneous antiemetics
https://themeditary.com/dosage-information/doxylamine-pyridoxine-dosage-10234.html

Doxylamine / Pyridoxine Dosage

Drug Detail:Doxylamine and pyridoxine (Doxylamine and pyridoxine [ dox-il-a-meen-and-pir-i-dox-een ])

Drug Class: Miscellaneous antiemetics

Contents
Uses Warnings Before Taking Dosage Side effects Interactions

Usual Adult Dose for Nausea/Vomiting

Doxylamine 10 mg-pyridoxine 10 mg delayed-release tablets:

  • Initial dose: 2 tablets orally once a day at bedtime
  • Maintenance dose: 2 tablets orally once a day to 4 tablets orally 3 times a day
  • Maximum dose: 4 tablets/day

Doxylamine 20 mg-pyridoxine 20 mg extended-release tablets:
  • Initial dose: 1 tablet orally once a day at bedtime
  • Maximum dose: 2 tablets/day

Comments:
  • Treatment should be taken as prescribed, and should not be taken on an as-needed basis.
  • Patients should be routinely reassessed for the continued need for treatment.

Use: Treatment of nausea and vomiting of pregnancy in patients who do not respond to conservative management

Renal Dose Adjustments

Data not available

Liver Dose Adjustments

Data not available

Dose Adjustments

Delayed-release tablets:

  • The dose may be continued if symptoms are adequately controlled.
  • If symptoms persist into the afternoon of Day 2: 2 tablets orally at bedtime on Day 2, THEN 3 tablets orally 2 times a day (1 tablet in the morning and 2 tablets at bedtime) on Day 3.
  • If 3 tablets adequately control symptoms, patients should continue to take this dose.
  • If symptoms persist into Day 4: 4 tablets orally 3 times a day (1 tablet in the morning, 1 tablet mid-afternoon, 2 tablets at bedtime)

Extended-release tablets:
  • The initial dose may be continued if symptoms are adequately controlled.
  • If symptoms are not controlled the next day, the dose may be increased to 1 tablet orally 2 times a day (in the morning and at bedtime).

Precautions

CONTRAINDICATIONS:

  • Hypersensitivity to either active component, other ethanolamine derivative antihistamines, or to any of the ingredients
  • MAO inhibitors

Safety and efficacy have not been established in patients younger than 18 years.

Consult WARNINGS section for additional precautions.

Dialysis

Data not available

Other Comments

Administration advice:

  • This drug should be taken on an empty stomach with a glass of water.
  • Tablets should not be chewed, crushed, or split.

Storage requirements:
  • Bottles should be kept tightly closed and protected from moisture when not in use.
  • Desiccant canisters should not be removed from the bottle.

General:
  • Limitation of use: This drug has not been studied in patients with hyperemesis gravidarum.

Patient advice:
  • Inform patients that this drug may cause somnolence, and they should avoid driving or operating machinery until patients are cleared to do so.
  • Patients should be instructed to avoid using other central nervous system depressants concomitantly during treatment.
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