Usual Adult Dose for Intraocular Hypertension

Instill 1 drop in the affected eye(s) twice a day, in the morning and at bedtime

Comments:

• If the tension fails to remain at an acceptable level on the usual regimen, a change in therapy is indicated.
• The once a day dose or one of the twice a day doses should always be instilled just before bedtime to avoid inconvenience due to the miosis.
• Twice a day dosing is preferred to once a day in order to maintain as smooth a diurnal tension curve as possible.

Usual Pediatric Dose for Strabismus

Diagnosis of accommodative esotropia: One drop may be instilled once a day in both eyes before bedtime, for a period of two or three weeks.

Comments:

• Favorable response will usually be noted within a few hours.

• The maximum usually recommended dosage is one drop once a day, although more intensive therapy has been used for short periods.

Renal Dose Adjustments

Data not available

Liver Dose Adjustments

Data not available

Dose Adjustments

• A once a day or every other day dose has been used with satisfactory results.

Precautions

CONTRAINDICATIONS:

• Hypersensitivity to any of the ingredients
• Active uveal inflammation
• Most cases of angle-closure glaucoma without iridectomy, due to the possibility of increasing angle block.

Dialysis

Data not available

Other Comments

Administration advice:

• Digital compression of the nasolacrimal ducts for a minute or two following instillation to minimize drainage into the nasal chamber is recommended.

• Prior to reconstitution: Refrigerate at 2C to 8 C.
• After reconstitution: Store at room temperature at approximately 25 C. Do not refrigerate. Discard any unused solution after 4 weeks.

• The manufacturer product information should be consulted.

• Tolerance may occasionally develop after prolonged use.
• Consider surgery if deviation recurs after about a year or two after gradually withdrawing this drug.
• Wash hands before and after instillation.