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Home > Drugs > Gonadotropin releasing hormones > Eligard > Eligard Dosage
Gonadotropin releasing hormones
https://themeditary.com/dosage-information/eligard-dosage-340.html

Eligard Dosage

Drug Detail:Eligard (Leuprolide [ loo-proe-lide ])

Generic Name: LEUPROLIDE ACETATE 45mg in 0.375mL

Dosage Form: injection, suspension, extended release

Drug Class: Gonadotropin releasing hormones Hormones / antineoplastics

Contents
Uses Warnings Before Taking Dosage Side effects Interactions FAQ

Recommended Dosage

ELIGARD 45 mg is administered subcutaneously every 6 months and provides continuous release of leuprolide acetate over a six-month treatment period. ELIGARD must be administered by a healthcare provider. The injection delivers the dose of leuprolide acetate incorporated in a polymer formulation.

As with other drugs administered by subcutaneous injection, the injection site should vary periodically. The specific injection location should be an area with sufficient soft or loose subcutaneous tissue. In clinical trials, the injections were administered in the upper- or mid-abdominal area. Avoid areas with brawny or fibrous subcutaneous tissue or locations that could be rubbed or compressed (i.e., with a belt or clothing waistband).

Mixing Procedure

Use aseptic technique throughout the procedure. As with other similar agents, the use of gloves is recommended during mixing and administration.1 Allow the product to reach room temperature before mixing. Once mixed, the product must be administered within 30 minutes or it should be discarded.

ELIGARD is packaged in a carton containing:

  • Tray containing pre-connected syringe system and desiccant pack
  • Prescribing information
  • Sterile safety needle and cap (located under the tray in carton)

Follow the detailed instructions below to ensure correct preparation of ELIGARD prior to administration:

Step 1

On a clean field open the tray by tearing off the foil from the corner and remove the contents. Discard the desiccant pack. Remove the pre-connected syringe system from the tray. Open the sterile safety needle package by peeling back the paper tab. Note: Syringe A and Syringe B should not be lined-up yet. The product should only be administered with the co-packaged, sterile safety needle.
mixing
Step 2

Grasp the latching button on the coupling device with your finger and thumb and press until you hear a snapping sound. The two syringes will be aligned.



Do not bend the pre-connected syringe system.
step 2

Step 3

Holding the syringes in a horizontal position, transfer the liquid contents of Syringe A into the leuprolide acetate powder contained in Syringe B. Thoroughly mix the product for 60 cycles by pushing the contents back and forth between both syringes to obtain a uniform suspension.

  • A cycle is one push of the Syringe A plunger and one push of the Syringe B plunger.
  • When thoroughly mixed, the suspension will appear colorless to pale yellow.

Note: Product must be mixed as described; shaking will NOT provide adequate mixing. Do not bend.

step3

Step 4

After mixing, hold the syringes vertically (upright) with Syringe B (wide syringe) on the bottom. The syringes should remain securely coupled. Transfer all of the mixed product into Syringe B by depressing the Syringe A plunger and slightly withdrawing the Syringe B plunger.
step4

Step 5

While ensuring the Syringe A plunger is fully pushed down, hold the coupling device and unscrew Syringe B. This will disconnect Syringe B from the coupling device. Syringe A will remain attached to the coupling device.

Note: Small air bubbles will remain in the formulation – this is acceptable.

Do not purge the air bubbles from Syringe B as product may be lost!

step5

Step 6

Continue to hold Syringe B upright with the open end at the top. Hold back the white plunger on Syringe B to prevent loss of the product and attach the safety needle and cap. Gently screw clockwise with approximately a three-quarter turn until the safety needle and cap are secure.

Do not overtighten, as the needle hub may become damaged which could result in leakage of the product during injection. The safety shield may also be damaged if the safety needle and cap are screwed with too much force.

step6

Step 7

Move the safety shield away from the needle and towards the syringe.

Pull off the cap immediately prior to administration.

figure 7

Note: Should the needle hub appear to be damaged, or leak, the product should NOT be used. The damaged safety needle and cap should NOT be replaced and the product should NOT be injected. In the event of damage to the needle hub, use a new replacement ELIGARD carton.


Administration Procedure

1. Select an injection site on the abdomen, upper buttocks, or another location with adequate amounts of subcutaneous tissue that does not have excessive pigment, nodules, lesions, or hair and hasn’t recently been used.

2. Cleanse the injection-site area with an alcohol swab (not enclosed).

3. Using the thumb and forefinger, grab and bunch the area of skin around the injection site.

admin-1
4. Using your dominant hand, insert the needle quickly at a 90° angle to the skin surface. The depth of penetration will depend on the amount and fullness of the subcutaneous tissue and the length of the needle. After the needle is inserted, release the skin.

5. Inject the drug using a slow, steady push and press down on the plunger until the syringe is empty.

Make sure all the drug has been injected before removing the needle.

6. Withdraw the needle quickly at the same 90° angle used for insertion.

admin

7. Immediately following the withdrawal of the needle, activate the safety shield using a finger/thumb or flat surface and push until it completely covers the needle tip and locks into place.

8. An audible and tactile “click” verifies a locked position.

9. Check to confirm the safety shield is fully engaged. Discard all components safely in an appropriate biohazard container.

step 7
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