Usual Adult Dose for Intraabdominal Infection

1 mg/kg IV every 12 hours for 4 to 14 days

Use: For the treatment of complicated intraabdominal infections due to susceptible Escherichia coli, Klebsiella pneumoniae, Citrobacter freundii, Enterobacter cloacae, K oxytoca, Enterococcus faecalis, E faecium, Staphylococcus aureus, Streptococcus anginosus group, Clostridium perfringens, Bacteroides species, Parabacteroides distasonis

Renal Dose Adjustments

Renal dysfunction: No adjustment recommended

Liver Dose Adjustments

Mild to moderate liver dysfunction (Child-Pugh A and B): No adjustment recommended
Severe liver dysfunction (Child-Pugh C):

• First day: 1 mg/kg IV every 12 hours
• Starting on second day: 1 mg/kg IV every 24 hours

Dose Adjustments

Coadministration with a weak or moderate CYP450 3A inducer: No adjustment recommended
Coadministration with a strong CYP450 3A inducer: 1.5 mg/kg IV every 12 hours
Total duration of therapy: 4 to 14 days

Precautions

CONTRAINDICATIONS:

• Known hypersensitivity to the active component, tetracycline-class antibacterial agents, or any of the ingredients

Dialysis

Data not available

Comments:

• Significant removal via hemodialysis is not expected.

Other Comments

Administration advice:

• Administer via IV infusion over about 60 minutes; administer through a dedicated line or through a Y-site.
• If the same IV line is used for sequential infusion of several drugs, flush the line before and after infusion of this drug with 0.9% Sodium Chloride Injection, USP.
• Must infuse diluted solutions within 24 hours if stored at room temperature or within 10 days if stored refrigerated.
• Use severity and location of infection and patient clinical response to guide duration of therapy.

• Powder (prior to reconstitution): Store vials at 2C to 8C (36F to 46F); keep vial in carton until use.
• Reconstituted solution: Stability in vial has been shown for 1 hour at room temperature (not to exceed 25C [77F]); if not diluted in the infusion bag within 1 hour, the reconstituted vial must be discarded. Do not freeze.
• Diluted solution: Must be infused within 24 hours if stored at room temperature (not to exceed 25C [77F]) or within 10 days if stored refrigerated at 2C to 8C (36F to 46F); do not freeze.

• Reconstitute vial(s) with Sterile Water for Injection, USP or 0.9% Sodium Chloride Injection, USP; swirl gently to dissolve.
• The reconstituted solution must be diluted further in a 0.9% Sodium Chloride Injection, USP infusion bag prior to IV infusion.
• The manufacturer product information should be consulted.

• Compatible: Sterile Water for Injection, USP; 0.9% Sodium Chloride Injection, USP
• Compatibility with other drugs and infusion solutions not established.
• This drug should not be mixed with other drugs or added to solutions containing other drugs.

• Limitations of Use: This drug is not indicated for the treatment of complicated urinary tract infections.
• To reduce the development of drug-resistant organisms and maintain effective therapy, this drug should be used only to treat or prevent infections proven or strongly suspected to be caused by susceptible bacteria.
• Culture and susceptibility information should be considered when selecting/modifying antibacterial therapy or, if no data are available, local epidemiology and susceptibility patterns may be considered when selecting empiric therapy.

• Avoid missing doses and complete the entire course of therapy.
• Notify health care provider immediately if you become pregnant during therapy.
• Do not breastfeed during therapy and for 4 days after the last dose.
• Contact health care provider at once if watery and bloody stools (with or without stomach cramps and fever) develop.

Frequently asked questions

• What type of drug is Xerava?