Drug Detail:Famvir (Famciclovir [ fam-sye-klo-veer ])
Generic Name: FAMCICLOVIR 125mg
Dosage Form: tablet, film coated
Drug Class: Purine nucleosides
Drug Detail:Famvir (Famciclovir [ fam-sye-klo-veer ])
Generic Name: FAMCICLOVIR 125mg
Dosage Form: tablet, film coated
Drug Class: Purine nucleosides
FAMVIR may be taken with or without food.
Herpes labialis (cold sores): The recommended dosage of FAMVIR for the treatment of recurrent herpes labialis is 1500 mg as a single dose. Therapy should be initiated at the first sign or symptom of herpes labialis (e.g., tingling, itching, burning, pain, or lesion).
Genital herpes:
Recurrent episodes: The recommended dosage of FAMVIR for the treatment of recurrent episodes of genital herpes is 1000 mg twice daily for 1 day. Therapy should be initiated at the first sign or symptom of a recurrent episode (e.g., tingling, itching, burning, pain, or lesion).
Suppressive therapy: The recommended dosage of FAMVIR for chronic suppressive therapy of recurrent episodes of genital herpes is 250 mg twice daily.
Herpes zoster (shingles): The recommended dosage of FAMVIR for the treatment of herpes zoster is 500 mg every 8 hours for 7 days. Therapy should be initiated as soon as herpes zoster is diagnosed.
Recurrent orolabial or genital herpes: The recommended dosage of FAMVIR for the treatment of recurrent orolabial or genital herpes in HIV-infected patients is 500 mg twice daily for 7 days. Therapy should be initiated at the first sign or symptom of a recurrent episode (e.g., tingling, itching, burning, pain, or lesion).
Dosage recommendations for adult patients with renal impairment are provided in Table 1 [see Use in Specific Populations (8.6), Clinical Pharmacology (12.3)].
Indication and Normal Dosage Regimen |
Creatinine Clearance (mL/min) |
Adjusted Dosage Regimen Dose (mg) |
Dosing Interval |
Single-Day Dosing Regimens | |||
Recurrent Genital Herpes 1000 mg every 12 hours for 1 day |
≥ 60 | 1000 | every 12 hours for 1 day |
40-59 | 500 | every 12 hours for 1 day | |
20-39 | 500 | single dose | |
< 20 | 250 | single dose | |
HD* | 250 | single dose following dialysis |
|
Recurrent Herpes Labialis 1500 mg single dose |
≥ 60 | 1500 | single dose |
40-59 | 750 | single dose | |
20-39 | 500 | single dose | |
< 20 | 250 | single dose | |
HD* | 250 | single dose following dialysis |
|
Multiple-Day Dosing Regimens | |||
Herpes Zoster 500 mg every 8 hours |
≥ 60 | 500 | every 8 hours |
40-59 | 500 | every 12 hours | |
20-39 | 500 | every 24 hours | |
< 20 | 250 | every 24 hours | |
HD* | 250 | following each dialysis | |
Suppression of Recurrent Genital Herpes 250 mg every 12 hours |
≥ 40 | 250 | every 12 hours |
20-39 | 125 | every 12 hours | |
< 20 | 125 | every 24 hours | |
HD* | 125 | following each dialysis | |
Recurrent Orolabial or Genital Herpes in HIV-Infected Patients 500 mg every 12 hours |
≥ 40 | 500 | every 12 hours |
20-39 | 500 | every 24 hours | |
< 20 | 250 | every 24 hours | |
HD* | 250 | following each dialysis |
*Hemodialysis