Purine nucleosides
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Famvir Dosage

Drug Detail:Famvir (Famciclovir [ fam-sye-klo-veer ])

Generic Name: FAMCICLOVIR 125mg

Dosage Form: tablet, film coated

Drug Class: Purine nucleosides

Contents
Uses Warnings Before Taking Dosage Side effects Interactions

FAMVIR may be taken with or without food.

2.1 Dosing Recommendation in Immunocompetent Adult Patients

Herpes labialis (cold sores): The recommended dosage of FAMVIR for the treatment of recurrent herpes labialis is 1500 mg as a single dose. Therapy should be initiated at the first sign or symptom of herpes labialis (e.g., tingling, itching, burning, pain, or lesion).

Genital herpes:

Recurrent episodes: The recommended dosage of FAMVIR for the treatment of recurrent episodes of genital herpes is 1000 mg twice daily for 1 day. Therapy should be initiated at the first sign or symptom of a recurrent episode (e.g., tingling, itching, burning, pain, or lesion).

Suppressive therapy: The recommended dosage of FAMVIR for chronic suppressive therapy of recurrent episodes of genital herpes is 250 mg twice daily.

Herpes zoster (shingles): The recommended dosage of FAMVIR for the treatment of herpes zoster is 500 mg every 8 hours for 7 days. Therapy should be initiated as soon as herpes zoster is diagnosed.

2.2 Dosing Recommendation in HIV-Infected Adult Patients

Recurrent orolabial or genital herpes: The recommended dosage of FAMVIR for the treatment of recurrent orolabial or genital herpes in HIV-infected patients is 500 mg twice daily for 7 days. Therapy should be initiated at the first sign or symptom of a recurrent episode (e.g., tingling, itching, burning, pain, or lesion).

2.3 Dosing Recommendation in Patients with Renal Impairment

Dosage recommendations for adult patients with renal impairment are provided in Table 1 [see Use in Specific Populations (8.6), Clinical Pharmacology (12.3)].

Table 1: Dosage Recommendations for Adult Patients with Renal Impairment
Indication and Normal Dosage
Regimen		 Creatinine Clearance
(mL/min)		 Adjusted Dosage
Regimen Dose (mg)		 Dosing Interval
Single-Day Dosing Regimens
Recurrent Genital Herpes
1000 mg every 12 hours for 1 day		 ≥ 60 1000 every 12 hours for 1 day
40-59 500 every 12 hours for 1 day
20-39 500 single dose
< 20 250 single dose
HD* 250 single dose following
dialysis
Recurrent Herpes Labialis
1500 mg single dose		 ≥ 60 1500 single dose
40-59 750 single dose
20-39 500 single dose
< 20 250 single dose
HD* 250 single dose following
dialysis
Multiple-Day Dosing Regimens
Herpes Zoster
500 mg every 8 hours		 ≥ 60 500 every 8 hours
40-59 500 every 12 hours
20-39 500 every 24 hours
< 20 250 every 24 hours
HD* 250 following each dialysis
Suppression of Recurrent
Genital Herpes
250 mg every 12 hours		 ≥ 40 250 every 12 hours
20-39 125 every 12 hours
< 20 125 every 24 hours
HD* 125 following each dialysis
Recurrent Orolabial
or Genital Herpes
in HIV-Infected Patients
500 mg every 12 hours		 ≥ 40 500 every 12 hours
20-39 500 every 24 hours
< 20 250 every 24 hours
HD* 250 following each dialysis

*Hemodialysis

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